RESEARCH PUBLICATIONS:

BOOKS

  1. J. J. DiStefano, III, Feedback and Control Systems, A. R. Stubberud & I. J. Williams, McGraw-Hill, New York, May 1967. Translated Editions in Spanish, McGraw-Hill de Mexico, 1972; Portuguese, McGraw-Hill do Brasil, Ltda, Sao Paulo-Rio de Janeiro, 1972; Italian, Etas Libri S.p.A., Milano, 1974; Hebrew, 1974; French, Ediscience/McGraw-Hill S.A., Paris, Systems Asservis 1, 1974, Systems Asservis 2, 1975; German, McGraw-Hill Book Co., GmbH, Dusseldorf, 1976; Japanese, McGraw-Hill Book Co., Japan, 1983.

  2. J. J. DiStefano, III, A.R. Stubberud, I.J. William, Feedback and Control Systems, Second Edition: Continuous (Analog) and Discrete (Digital), McGraw-Hill, New York, April 1990. Translated Editions in Spanish, McGraw-Hill (Bogota) 1992, Russian.
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CHAPTERS IN BOOKS

  1. L. Stark and J. J. DiStefano, III, ``An Improved Sampled Data Model of the Eye Movement Control System,'' Neurological Control Systems, L. Stark, ed., Plenum Press, New York, 1969, p. 290.

  2. J. J. DiStefano, III, ``The Thyroid Hormone Feedback Control System,'' in Applications of Engineering Principles in Physiology, J. H. U. Brown & D. S. Gann, eds., Academic Press, 1:261-289, 1973.

  3. J. J. DiStefano, III and D. A. Fisher, ``Peripheral Distribution and Metabolism of the Thyroid Hormones: a Primarily Quantitative Assessment,'' in International Encyclopedia of Pharmacology and Therapeutics, Section 101, The Thyroid: Physiology and Treatmet of Disease J. M. Hershman & G. A. Bray, eds., Pergamon Press, pp. 47-82, 1979.

  4. P. Mak & J. J. DiStefano, III, ``Optimal Control Policies for the Prescription of Clinical Drugs: Dynamics of Hormone Replacement for Endocrine Deficiency Disorders,'' in Control and Dynamic Systems: Advances in Theory and Application, C. T. Leondes, ed., Academic Press, pp. 2-41, 1979.

  5. J. J. DiStefano, III, ``Some Theoretical and Practical Considerations in Modeling and Experiment Design for Quantifying Physiological and Pharmacokinetic Systems,'' in Computers in Endocrinology, D. Rodbard & G. Forti, eds., Raven Press, New York, Vol. 14, pp. 259-275, 1984.

  6. J. J. DiStefano, III, ``Optimal Experiment Design in Plasma Protein Metabolism Studies: Sequential Optimal Sampling Schedules for Quantifying Kinetics,'' in Pathophysiology of Plasma Protein Metabolism, G. Mariani, ed., McMillan, London, pp.15-34, 1984.

  7. J. J. DiStefano, III, ``Modeling Approaches and Models of the Distribution and Disposal of Thyroid Hormones,'' in Thyroid Hormone Metabolism, G. Hennemann, ed., Marcel Dekker, New York, pp. 39-76, 1985.

  8. K. R. Godfrey and J. J. DiStefano, III, "Identifiability of Model Parameters," Chapter 1, in Identifiability of Parameteric Models, (E. Walter, ed.), Pergamon Press, pp. 1-20, 1987.

  9. J. J. DiStefano, III, ``Hormone Kinetic Analysis,'' Chapter 160, in Endocrinology Second Edition, L. J. DeGroot, ed., Grune & Stratton, Inc., Florida, pp. 2726-2740, 1989.

  10. J. J. DiStefano, III, ``Biomodel Formulation and Identification Using Optimal and Other Effective Experiment Designs", Chapter 1 in: Modeling and Control in Biomedical Systems, C. Cobelli and L. Mariani, Eds., Pergamon Press, pp. 1-12, 1989.

  11. J. J. DiStefano, III, "Kinetic Modeling Methods in Theory and Practice", Chapter 5, in Thyroid Hormone Metabolism-Regulation and Clinical Implications, Blackwell Scientific Publications, Inc., pp. 65-89, 1991.
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EDITORIALS

  1. J. J. DiStefano, III, ``Modeling Methodology Forum: a New Department,'' editorial, American Journal of Physiology, 9:R257, 1981.

  2. J. J. DiStefano, III, ``Noncompartmental vs. Compartmental Analysis: Some Bases for Choice,'' American Journal of Physiology, 243: R1-R6, 1982.

  3. J. J. DiStefano, III, ``Mones Berman -- a Special Tribute,'' American Journal of Physiology, 245:R617, 1983.

  4. J. J. DiStefano, III, ``Modeling Methodology Forum,'' American Journal of Physiology, 248:E153, 1985.

  5. S. M. Yamashiro, C-S. Poon, J. J. DiStefano, III, "Modeling Pioneer: Fred S. Grodins (1915-1989)", Journal of Applied Physiology (JAP): Modeling Methodology Forum, No. 6, 70:2763, 1991.

  6. J. J. DiStefano, III, "The Review Process for Modeling Papers: A Revisionist's Experience with the Conventional Model", Amerian Journal of Physiology, 30:E485-486, 1994.
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RESEARCH PAPERS

  1. J. J. DiStefano, III, "Pizza alla DiStefano,'' (a recipe) Sunset Magazine, 130:184, Lane Magazine Co., Menlo Park, CA., March 1963.
  2. J.J. DiStefano, III, "Design for a Digitally-Rebalanced Closed-Loop Velocity Meter Providing a Discrete Output,'' IEEE Transactions on Aerospace, AS-2:1059-1064, 1964.

  3. J.J. DiStefano, III, "The Choice of State Variables for the Determination of the Stability of Nonlinear Systems Utilizing the Second Method of Liapunov,'' IEEE Transactions on Automatic Control, AC- 9:279:280, 1964.

  4. J.J. DiStefano, III, E.B. Stear & G. P. Moore, "A Model of the Thyroid Hormone Regulator and a Proposal for Its Experimental Validation,'' In Proceedings of the 19th Annual Conf. on Engineering in Medicine and Biology, 8:3, 1966.


  5. J.J. DiStefano, III, and E. B. Stear, "Neuroendocrine Control of Thyroid Secretion in Living Systems: a Feedback Control System Model,'' Bulletin, Math. Biophysics, 30:3-26, 1968.

  6. J.J. DiStefano, III, and E. B. Stear, "On Identification of Hypothalamo-Hypophysial Control and Feedback Relationships with the Thyroid Gland,'' Journal of Theoretical Biology, 19:29-50, 1968.

  7. J.J. DiStefano, III, "Endocrine Regulation: Models and Experimental Design for System Identification,'' Proceedings, Seminar on Large Scale Systems in the Mathematical Biosciences, Dubrovnik, Yugoslavia, 1968.

  8. J.J. DiStefano, III, "A Model of the Regulator of Circulating Thyroxin Unbound and Bound to Plasma Proteins and Its Response to Pregnancy, Drugs, Long Acting Thyroid Stimulator and Temperature Stress,'' Math. Biosci. 4:137-152, 1969.

  9. J.J. DiStefano, III, and E. B. Stear, "Modeling and Control Aspects of Thyroid Function,'' Proceedings, Conference on Hormonal Control Systems in Health and Disease, Supplement 1, Math. Biosci., American Elsevier Publishing Co., New York, 1969.

  10. J.J. DiStefano, III, "Hypothalamic and Rate Feedback in the Thyroid Hormone Regulation System: a Hypothesis,'' Bulletin, Math. Biophysics., 31:233-246, 1969.

  11. J.J. DiStefano, III, "A Model of the Normal Thyroid Hormone Glandular Secretion Mechanism,'' Journal of Theoretical Biology, 22:412-417, 1969.

  12. J.J. DiStefano, III, "Are There Extrathyroidal Sources of Thyroid Hormones?'' Journal of Physiol. Chemistry and Physics, 1:164,170, 1969.

  13. J.J. DiStefano, III, G. Scuncio & I. Baschieri, "Oscillations in the Rate of Disappearance of Labeled Triiodothyronine from Human Plasma and the Minimum Sampling Rate for their Observation,'' Experientia, 26:312- 313, 1970.

  14. J.J. DiStefano, III, "Thyroid Hormone Regulation: Models and Simulations,'' Proceedings, 3rd Hawaii Int'l. Conf. on Systems Sciences, Part 1, pp. 223-226, Western Periodicals Co., 1970.

  15. J.J. DiStefano, III and R. F. Chang, "Computer Simulation of the Kinetics of Binding, Distribution and Metabolism of Thyroxine and Triiodothyronine in Man,'' In Proceedings, Further Advances in Thyroid Research, 6th Int'l. Thyroid Conf., Vienna, 1970, K. Fellinger and R. Hofer, eds., Verlag der Wiener Medizinischen Akademie, Vienna, 1971, pp. 351-361.

  16. J.J. DiStefano, III and R. F. Chang, "Computer Simulation of Thyroid Hormone Binding, Distribution and Disposal Dynamics in Man,'' American Journal of Physiology, 221:1529-1544, 1971.


  17. J.H. Dussault, C. J. Hobel, J. J. DiStefano, III, A. Erenberg & D. A. Fisher, "Triiodothyronine Turnover in Maternal and Fetal Sheep,'' Endocrinology, 90:1301-1308, 1972.

  18. J. DiStefano, III, "Precision Microbicannulation Device for Neuroendocrine or Neurophysiologic Applications,'' Journal of Applied Physiology, 33:159-163, 1972.

  19. G.E. Abraham, E. M. Reifman, J. E. Buster, J. J. DiStefano, III, & J. R. Marshall, "Production of Specific Antibodies Against Diethylstilbestrol,'' Analytical Letters, 5:479-486, 1972.

  20. K.C. Wilson, M. Jang, P. Mak & J. J. DiStefano, III, "Identification of the Dynamics of Thyroid Hormone Binding Distribution and Disposal,'' Proceedings, 3rd IFAC Symposium on Identification and System Parameter Estimation, North Holland Publishing Co., Amsterdam, 1973, pp. 203-208.

  21. J.J. DiStefano, III, A. R. Durando, M. Jang, D. Jenkins, D. J. Johnson, P. Mak, T. Marshall, B. Mons, A. Warsavsky & D. A. Fisher, "Estimates and Estimation Errors of Hormone Secretion, Transport and Disposal Rates in the Maternal-Fetal System,'' Endocrinology, 93:324-342, 1973.

  22. M.L. Ownby and J. J. DiStefano, III, "Parameter Estimation for Nonlinearly Observed Dynamic Systems: a Modified Quasilinearization Approach,'' Proceedings, 6th Annual Southeastern Symposium on System Theory, 1974.

  23. A. Kojima, J. M. Hershman, M. Azukizawa and J. J. DiStefano, III, "Quantification of the Pituitary-Thyroid Axis in Pregnant Rats,'' Endocrinology, 96:599-605, 1974.

  24. M. Mayekawa, J. J. DiStefano, III, & R. Swerdloff, "A Dynamic System Model of Testosterone Transport and Metabolism in Normal Man,'' Annals of Biomedical Engineering, 2:307-320, 1974.

  25. J.J. DiStefano, III, "Use of Systems and Control Theories in Endocrinology and Metabolism,'' in "Measurements, Models and Noise in Endocrine and Metabolic Systems: a Symposium Summary,'' Kroc Foundation Conference Report 1, pp. 7-9, 1974.

  26. J.J. DiStefano, III, K. Wilson, M. Jang & P. H. Mak, "Identification of the Dynamics of Thyroid Hormone Metabolism,'' Automatica, 11:149-159, March 1975.

  27. J.J. DiStefano, III, "In Numero Studies in Endocrinology and Metabolism: toward Computer-Aided Experimental Design,'' Proceedings, 6th Summer Computer Simulation Conference, 2:935-938, July 1975.

  28. J.J. DiStefano, III, "Tracer Experiment Design for Unique Identification of Nonlinear Physiological Systems,'' American Journal of Physiology, 230:476-485, 1976.

  29. J.J. DiStefano, III, and D. A. Fisher, "Peripheral Distribution and Metabolism of the Thyroid Hormones: a Primarily Quantitative Assessment,'' Pharmacology and Therapeutics, 2:539-570, 1976.

  30. J.J. DiStefano, III, "Concepts, Properties, Measurement and Computation of Clearance Rates of Hormones and Other Substances in Biological Systems,'' Annals of Biomedical Engineering, 4:302-319, 1976.

  31. K. Wilson, D. A. Fisher, J. Sack & J. J. DiStefano, III, "System Analysis and Estimation of Key Parameters of Thyroid Hormone Metabolism in Sheep,'' Annals of Biomedical Engineering, 5:70-84, 1977.

  32. J.J. DiStefano, III, "On the Relationships Between Structural Identifiability and the Controllability, Observability Properties,'' IEEE Transactions on Automatic Control, AC-22:652, 1977.

  33. J. J. DiStefano, III, and F. Mori, "Parameter Identifiability and Experiment Design: Thyroid Hormone Metabolism Parameters,'' American Journal of Physiology, 233:R134-R144, 1977.

  34. R.E. Weitzman, D. A. Fisher, J. J. DiStefano, III, & C. M. Bennett, "Episodic Secretion of Arginine Vasopressin,'' American Journal of Physiology, 233:E32-E36, 1977.

  35. H. Mak and J. J. DiStefano, III, "Optimal Control Policies for the Prescription of Thyroid Hormones,'' Math. Biosciences, 42:159-186, 1978.

  36. P. Hagander, K-G. Tranberg, J. Thorell & J. J. DiStefano, III, "Models for the Insulin Response to Intravenous Glucose Loads,'' Math. Biosciences, 42:15-29, 1978.

  37. J. J. DiStefano, III, "Optimal Design of Physiological Experiments,'' Proc., Joint Automatic Control Conf., Philadelphia, PA., , 4:43-52, 1978.

  38. J. J. DiStefano, III, reply to "Comments on the Relationships between Structural Identifiability and Controllability, Observability Properties,'' by C. Cobelli, A. Lepschy & G. Romanin-Jacur, IEEE Transactions on Automatic Control, 23:5, 1978.

  39. J.J. DiStefano, III, reply to "Comments on Necessary Conditions for Identifiability of Linear Systems,'' by J. A. Jacquez, IEEE Transactions on Automatic Control, 23:5, 1978.

  40. J.R. Sowers, A. E. Pekary, J. M. Hershman, M. Kanter & J. J. DiStefano, III, "Metabolism of Exogenous Human Chorionic Gonadotrophin in Men,'' Journal of Endocrinology, 80:83-89, 1979.

  41. H.V. Roohk, M. Azukizawa, J. J. DiStefano, III, T. Ogihara & J. M. Hershman, "Pituitary-Thyroid Hormone Periodicities in Serially-Sampled Plasma of Unanesthetized Rats,'' Endocrinology, 104:851-856, 1979.

  42. F. Mori and J. J. DiStefano, III, "Optimal Nonuniform Sampling Interval and Test Input Design for Identification of Physiological Systems from Very Limited Data,'' IEEE Transactions on Automatic Control, 104:893-899, 1979.

  43. J.J. DiStefano, III, and P. H. Mak, "On Model and Data Requirements for Determining the Bioavailability of Oral Therapeutic Agents: Application to Gut Absorption of Thyroid Hormones,'' American Journal of Physiology, 236:R137-R141, 1979.

  44. J.R. Allsop, R. R. Wolfe, J. J. DiStefano, III, & J. F. Burke, "The Reliability of Rates of Glucose Appearance in Vivo Calculated from Single Tracer Injections,'' Canadian Journal of Physiology and Pharmacology, 57:1267-1274, 1979.

  45. J.J. DiStefano, III, "Matching the Model and the Experiment to the Goals: Data Limitations, Complexity and Optimal Experiment Design for Dynamic Systems with Biochemical Signals,'' Journal of Cybernetics and Information Science, 2:6-20, 1979.

  46. J.J. DiStefano, III, "Comments on Optimal Screening, Recall and Treatment of Congenital Hypothyroidism in Newborn Infants,'' In Proceedings of the Int'l. Conf. on Neonatal Thyroid Screening, Quebec, Canada, September 20-23, 1979.

  47. J.J. DiStefano, III, "Design and Optimization of Tracer Experiments in Physiology and Medicine,'' Federation Proceedings, 39:84-90, 1980.

  48. C. Cobelli and J. J. DiStefano, III, "Parameter and Structural Identifiability Concepts and Ambiguities: a Critical Review and Analysis,'' American Journal of Physiology 239:R7-R24, 1980.

  49. J. J. DiStefano, III, & C. Cobelli, "On Parameter and Structural Identifiability: Nonunique Observability/Reconstructability for Identifiable Systems, Other Ambiguities and New Definitions,'' IEEE Transactions on Automatic Control, AC-25:830-833, 1980.

  50. J.J. DiStefano and C. Cobelli, authors' reply to Lecourtier and Walter, IEEE Transactions on Automatic Control, AC-26:801-802, June 1981.

  51. K. Okamura, A. Taurog, and J. J. DiStefano, III, "Elevated Serum Levels of T3 Without Metabolic Effect in Nutritionally Deficient Rats, Attributable to Reduced Cellular Uptake of T3,'' Endocrinology, 109:673- 675, 1981.

  52. J.J. DiStefano, III, "Optimized Blood Sampling Protocols and Sequential Design of Kinetic Experiments,'' American Journal of Physiology, 9:R259- R265, 1981.

  53. J.J. DiStefano, III, T. K. Malone & M. Jang, "Comprehensive Kinetics of Thyroxine (T4) Distribution and Metabolism in Blood and Tissue Pools of the Rat from Only 6 Blood Samples: Dominance of Large, Slowly Exchanging Tissue Pools,'' Endocrinology, 111:108-117, 1982.

  54. J.J. DiStefano, III, M. Jang, T. K. Malone & M. Broutman, "Comprehensive Kinetics of Triiodothyronine (T3) Production, Distribution and Metabolism in Blood and Tissue Pools of the Rat Using Optimized Blood Sampling Protocols,'' Endocrinology, 110:198-213, 1982.

  55. J. J. DiStefano, III, "Experiences with Sequential Optimal Sampling Schedule Designs for Pharmacokinetics and Physiologic Experiments,'' Proceedings, 10th IMACS World Congress on Systems Simulation and Scientific Computation, Volume 2, pp. 203-205, 1982.

  56. C.R. Markussen and J. J. DiStefano, III, "Evaluation of Four Methods for Computing Parameter Sensitivities in Dynamic System Models,'' Math. Biosciences, 61:135-148, 1982.

  57. J.J. DiStefano, III, "Noncompartmental vs. Compartmental Analysis: Some Bases for Choice,'' American Journal of Physiology, 243: R1-R6, 1982.

  58. J.J. DiStefano, III, "Algorithms, Software and Sequential Optimal Sampling Schedule Designs for Pharmacokinetic and Physiologic Experiments,'' Mathematics & Computers in Simulation, Vol. 24, 531-534, 1982.

  59. J.J. DiStefano, III, "Comprehensive Dynamics of Distribution and Metabolism of Thyroid Hormones in Blood and Tissue Pools Using Sequentially Optimized Experiment Designs and A Priori Inequality Analysis,'' In Proceedings of the 6th IFAC (International Federation of Automatic Control) Symposium on Identification and System Parameter Estimation, Pergamon Press, New York, pp. 1027-1032, 1983.

  60. C. Cobelli, J. J. DiStefano, III, L. Okolicsaniji & A. Ruggeri, "Minimal Sampling Schedules for Identification of Dynamic Models of Metabolic Systems of Clinical Interest: Case Studies for Two Liver Function Tests,'' Math. Biosciences, 63:173-186, 1983.

  61. J. J. DiStefano, III, "Complete Parameter Bounds and Quasiidentifiability of Some Unidentifiable Linear Systems,'' Math. Biosciences. 65:51-68, 1983.

  62. J.J. DiStefano, III, "Models of the Control of Distribution and Metabolism of Thyroid Hormone in Several Species: Comparative Aspects,'' In Proceedings of the 9th World Congress, Intenational Federation of Automatic Control (IFAC), Budapest, Hungary, 6:103-108, 1984.

  63. J.J. DiStefano, III, "Some Theoretical and Practical Considerations in Modeling and Experiment Design for Quantifying Physiological and Pharmacokinetic Systems,'' in International Symposium on Computers in Endocrinology, Porto Cervo, Italy, Raven Press, pp.259-275, 1984.

  64. J.J. DiStefano, III, "Workshop: Identifiability and Statistical Properties of Models and Optimization of Experiment Design,'' in International Symposium on Computers in Endocrinology, Porto Cervo, Italy, Raven Press, 1984.

  65. J.J. DiStefano, III, and E. Landaw, "Multiexponential, Multicompartmental and Noncompartmental Modeling: Physiological Data Analysis and Statistical Considerations, Part I: Methodological and Physiological Interpretations,'' American Journal of Physiology, 246:R651-R664, 1984.

  66. E. Landaw and J. J. DiStefano, III, "Multiexponential, Multicompartmental and Noncompartmental Modeling: Physiological Data Analysis and Statistical Considerations, Part II, Data Analysis and Statistical Considerations,'' American Journal of Physiology, 246:R665- R677, 1984.

  67. J.L. Specker, J. J. DiStefano, III, R. S. Nishioka & H. A. Bern, "Development-Associated Changes in Thyroxine Kinetics in Juvenile Salmon,'' Endocrinology, 115:399-406, 1984.

  68. E.M. Landaw, B. C-M. Chen & J. J. DiStefano, III, "An Algorithm for the Identifiable Parameter Combinations of the General Mamillary Compartmental Model,'' Math. Biosciences, 72:199-212, 1984.

  69. J.J. DiStefano, III, reply to Claudio Cobelli & Gianna Toffolo re: "Identifiability from Parameter Bounds -- Structural & Numerical Aspects,'' Math. Biosciences, 71:245-246, 1984.

  70. J.J. DiStefano, III, M. Jang & M. Kaplan, "Optimized Kinetics of Reverse-Triiodothyronine (rT3) Distribution and Metabolism in the Rat: Dominance of Large, Slowly Exchanging Tissue Pools for Iodothyronines,'' Endocrinology, 116:446-456, 1985.

  71. M. Jang and J. J. DiStefano, III, "Some Quantitative Changes in Iodothyronine Distribution and Metabolism in Mild Obesity and Aging,'' Endocrinology, 116:457-468, 1985.

  72. Cobelli, A. Ruggeri, J. J. DiStefano, III, & E. M. Landaw, "Optimal Design of Multioutput Sampling Schedules -- Software & Applications to Endocrine Metabolic & Pharmacokinetic Models,'' IEEE Transactions on Biomedical Engineering, BME-32:249-256, 1985.

  73. B. C-M. Chen, E. M. Landaw & J. J. DiStefano, III, "Algorithms for the Identifiable Parameter Combinations and Parameter Bounds of Unidentifiable Catenary Compartmental Models,'' Math. Biosciences, 76:59-68, 1985.

  74. K.R. Godfrey and J. J. DiStefano, III, "Identifiability of Model Parameters," In Proceedings of the 7th IFAC/IFORS Symposium of Identification & System Parameter Estimation, 1:89-114, 1985.

  75. J. Hershman, K. Nademanee, M. Sugawara, A. E. Pekary, R. Ross, B. Singh & J. J. DiStefano, III, "Thyroxine and Triiodothyronine Kinetics in Cardiac Patients Taking Amiodarone," Acta Endocrinologica, 111:193-199, 1986.

  76. J. Fagarasan & J. J. DiStefano, III, "Hidden Pools, Hidden Modes and Visible Repeated Eigenvalues in Compartmental Models," Mathematical Biosciences, 82:87-113, 1986.

  77. J. Fagarasan & J. J. DiStefano, III, "On the Visibility of Leading Eigenvalues in Compartmental Models," Mathematical Biosciences, 86:97- 110, 1987.

  78. J.J. DiStefano, III & Viveca Sapin, "Fecal and Urinary Excretion of Six Iodothyronines in the Rat," Endocrinology, 121:1742, 1987.

  79. J.J. DiStefano, III, "Excretion, Metabolism and Enterohepatic Circulation Pathways and Their Role in Overall Thyroid Hormone Regulation in the Rat," The American Zoologist, 28: 373-388, 1988.

  80. J.J. DiStefano, III, B. C. Chen & E. M. Landaw, "Pool Size and Mass Flux Bounds and Quasiidentifiability Conditions for Catenary Models," Mathematical Biosciences, 88:1-14, 1988.

  81. B.L. Chang, J. J. DiStefano, III, K. Roth, E. Gonzales, D. Caswell, "CANDI: A Knowledge-Based System for Nursing Diagnosis," Computers in Nursing, 6:13-22, 1988.

  82. R. Lindell, J. J. DiStefano, III & E. Landaw, "Statistical Variability of Parameter Bounds for n-pool Unidentifiable Mammillary and Catenary Compartmental Models," Mathematical Biosciences, 91:175-199, 1988.

  83. J.J. DiStefano, III, D. Feng, "Comparative Aspects of the Distribution, Metabolism and Excretion of 6 Iodothyronines in the Rat", Endocrinology, 123:2514-2525, 1988.

  84. J.J. DiStefano, III, M. Sternlicht and D. Harris, "Rat Enterohepatic Circulation and Intestinal Distribution of Enternally-Infused Thyroid Hormones", Endocrinology, 123:2526-2539, 1988.

  85. J.J. DiStefano, III , "Biomodel Formulation and Identification Using Optimal and Other Effective Experiment Designs," In Proceedings of the 1st IFAC Symposium on Modelling and Control in Biomedical Systems, Venice, Italy, pp. 1-12, April 1988.

  86. J. F. Fagarasan & J. J. DiStefano, III, "Hidden Oscillations in Generalized Mammillary Compartmental Models," Mathematical Biosciences, 93:79-95, 1989.

  87. K. Roth, J.J. DiStefano, III, B.L. Chang, "CANDI: Development of the Automated Nursing Assessment Tool", Computers In Nursing, 7:222-227, 1989.

  88. S. Vajda, J. J. DiStefano, III, K. Godfrey & J. Fagarasan, "Parameter Space Boundaries for Unidentifiable Compartmental Models," Mathematical Biosciences, 97:27-60, 1989.

  89. R.L. Stephens, Jr., A. E. Pekary, J. J. DiStefano, III, E. Landaw and Y. Tache, "Intracisternal Injection of TRH Precursor, TRH-Glycine, Stimulates Gastric Acid Secretion in Rats", Regulatory Peptides, 25:51- 60, 1989.

  90. A.E. Pekary, R. S. Stephens, M. Simard, X-P. Pang, V. Smith, J. J. DiStefano, III, J. M. Hershman, "Release of Thyrotropin and Prolactin by a Thyrotropin-Releasing Hormone (TRH) Precursor, TRH-Gly: Conversion to TRH is Sufficient for In Vivo Effects", Neuroendocrinology, 52:618-625, 1990.

  91. D. Feng, J. J. DiStefano, III, "Cut Set Analysis of Compartmental Models With Applications to Experiment Design", American Journal of Physiology: Endocrinology & Metabolism, 261:E269-E284, 1991.

  92. J.J. DiStefano, III, T. T. Nguyen, Y-M. Yen, O. Bres, "Biliary Fluxes, Lymphatic Effluxes and Relative Uptake Dynamics of 3,5,3'-Triiodothyronine (T3) and Thyroxine (T4) from Blood to Rat Intestines, Liver and Kidneys In Vivo", In: Progress in Thyroid Research (A. Gordon, J. Gross and G. Hennemann, eds), Rotterdam, pp. 809-811, 1991.

  93. A. Marino, J. J. DiStefano, E. M. Landaw, "DIMSUM: An Expert System for Multiexponential Model Discrimination", American Journal of Physiology: Endocrinology & Metabolism, 262:E546-556, 1992.

  94. D. Feng, J. J. DiStefano, III, "Decomposition-Based Qualitative Experiment Design Algorithms for Compartmental Models", Mathematical Biosciences, 110:27-43, June 1992.

  95. J. J. DiStefano, III, T. T. Nguyen, Y-M. Yen, "Sites and Patterns of Absorption of 3,5,3-Triiodothyronine (T3) and Thyroxine (T4) Along Rat Small and Large Intestines", Endocrinology, 131:275-280, July 1992.

  96. J.J. DiStefano, III, W. Morris, T. T. Nguyen, A. Van Herle, W. Florsheim, "Enterohepatic Regulation and Metabolism of Triiodothyronine (T3) in Hypothyroid Rats", Endocrinology, 132:1665-1670, 1993.

  97. J.J. DiStefano, III, T. T. Nguyen, Y-M. Yen, "Transfer of 3,5,3- Triiodothyronine (T3) and Thyroxine (T4) from Rat Blood to Small and Large Intestines, Liver and Kidneys In Vivo", Endocrinology, 132:1735- 1744, 1993.

  98. J.J. DiStefano, III, A. de Luze, T. T. Nguyen, "Binding and Degradation of 3,5,3'-Triiodothyronine (T3) and Thyroxine (T4) by Rat Intestinal Bacteria", Am. J. Physiology: Endocrinology & Metabolism, 264:966-972, 1993.

  99. T.T. Nguyen, L-M. Huang, J.J. DiStefano, III, H. Yamada, H.J. Cahnmann, "5'- and 5-Deiodinase Activity in Adult Rat Intestinal Contents Inhibited by Intestinal Microflora", American J. Physiology: Endocrinology & Metabolism, 265:E521-E524, 1993.

  100. T.T. Nguyen, J.J. DiStefano, III, H. Yamada, Y-M. Yen, "Steady state organ distribution & metabolism of thyroxine (T4) & 3,4,3'- triiodothyronine (T3) in intestines, liver, kidneys, blood & residual carcass of the rat in vivo", Endocrinology, 133:2973-2983, 1993.

  101. K. Okimoto, J. J. DiStefano, III, T. T. Kuwaye, G. M. Weber, B. Ron, T. T. Nguyen, S. K. Shimoda, E. G. Grau, "Plasma Volume in the Tilapia, Oreochromis Mossambicus, Maintained in Fresh Water", Fish Physiol. Bioch. Journal, 12:431-438, 1994.

  102. Y-M. Yen, H. Yamada, J.J. DiStefano, III, and T.T. Nguyen. "Direct Measurement of Whole-Body Thyroid Hormone Pools Sizes and Interconversion Rates in Fasted Rats: Hormone Regulation Implications" Endocrinology, 134:1700-1709, 1994.

  103. A.B. Kuhn de Chizelle, J.J. DiStefano, III. "MAMCAT: An expert system for distinguishing between mammillary and catenary compartmental models", Computers in Biology & Medicine, 24:189-204, 1994.

  104. J. J. DiStefano, III, P. Waechter, P. Abramowitz, H. T. Su, and T. T. Nguyen. " Expert system-knowledge based biomodeling." In Proceeding of the IFAC Symposium on Modeling and Control in Biomedical Systems, Galveston TX, pp. 1 – 6, March 1994.

  105. D. Feng, J.J. DiStefano, III, "An algorithm for identifiable parameters and parameter bounds for a class of cascaded mamillary models", Mathematical Biosciences, 129:67-93, 1995.

  106. A. Sefkow, J.J. DiStefano, III, J.G. Eales, B.A. Himick, S.B. Brown. Thyroid hormone secretion and interconversion in 5-day fasted rainbow trout, Oncorhynchus Mykiss", General & Comp. Endocrinology, 101:123-138, 1996.

  107. J. P. Schroeder-van der Elst, D. van der Heide, E. Kaptein, T.J. Visser, and J. J. DiStefano, III, "Differential effects of 5,5'- diphenylhydantoin on thyroid hormone metabolism and action in rats", European J. of Endocrinology, 134:221-224, 1996.

  108. H. Yamada, J.J. DiStefano, III, Y-M. Yen and T.T. Nguyen, "Regulation of Whole Body Pool Sizes and Interconversion Rates of Thyroid Hormones in Hypo- and Mildly T3-Stimulated Rats", Endocrinology, 137:5624-5633, 1996.

  109. J.J. DiStefano, III, B. Ron, T.T. Nguyen, G.M. Weber, E.G. Grau, "3,5,3’-Triiodothyronine (T3) Clearance and T3-Glucuronide appearance kinetics in plasma of freshwater-reared male tilapia, Oreochromis mossambicus. Gen. Comp. Endo. 111:123-140, 1998.

  110. T.T Nguyen, Chapa, F., J.J. DiStefano, III. Direct Measurement of the Contributions of Type I (D1) and II (D2) 5’-Deiodinases to Whole-Body Steady State T3 Production from T4 in the Rat. Endocrinology, 139:4626-4633, 1998.

  111. P. Vicini, H.T. Su, J.J. DiStefano, III. "Identifiability and Interval Identifiability of Mammillary & Catenary Compartmental Models with Rate Parameter Constraints", Math. Biosciences, 167: 145-161, 2000.

  112. T.T Nguyen, Mol, K., J.J. DiStefano, III. "Thyroid Hormone Production by Liver and Intestines of the Rat In Vivo: A Graph Theory/Experimental Solution for Local Sources in an Inhomogeneous Multisource Biosystems". Submitted to American Journal of Physiology: Endocrinology and Metabolism, April 2002.

  113. T.T Nguyen, Chapa, F., J.J. DiStefano, III. Direct Measurement of the Contributions of Type I (D1) and II (D2) 5'-Deiodinases to Whole-Body Steady State T3 Production from T4 in the Rat. Endocrinology, 139:4626-4633, 1998.

  114. L.H. Duntas, T.T. Nguyen, F.S. Keck, D.K. Nelson, J. J. DiStefano III. " Changes in Metabolism of TRH in Euthyroid Sick Syndrome. European Journal of Endocrinology, 141:1-5, 1999

  115. C. Harless and JJ DiStefano III. "Automated Biomodeling for the World-Wide Web" In Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, Vol II, CSREA Press, pp. 528-533, 2003.

  116. T.T. Nguyen, Mol, K., J.J. DiStefano, III. "Thyroid Hormone Production by Rat Liver and Intestine In Vivo: A Novel Graph Theoretic/Experimental Solution". American Journal of Physiology: Endocrinology & Metabolism, 285:E171-181, 2003.

  117. P. Charusanti, X Hu, L Chen, D Neuhauser, and J. J. DiStefano III "A math model of bcr-abl autophosphorylation, signaling through the crkl pathway, and Gleevec dynamics in chronic myeloid leukemia" Discrete and Continuous Dynamic Systems, Series B, 4:99-114, 2004

  118. D. Tee & JJ DiStefano III. "Simulation of Tumor-Induced Angiogenesis and its Response to Anti-Angiogenic Drug Treatment: Mode of Drug Delivery and Clearance Rate Dependencies". Cancer Research and Clinical Oncology, 130:15-24, 2004

  119. S. Pallud, Kelly R, DiStefano JJ III, Parlow AF, Galton VA, StGermain D. "Metabolic Effect of Targeted Expression of Type 2 Iodothyroinine Deiodinase to Rodent Liver". Mol Endocin Submitted (In Revision).

  120. K. Bulis and JJ DiStefano III. W3MCSim: An Interactive, Intuitive and Pedagogically Useful Monte Carlo Simulator. Computer Methods and Programs in Biomedicine, 77:71-79, 2005. http://dx.doi.org/10.1016/j.cmpb.2004.08.001

  121. C. Harless and JJ DiStefano III. Automated Expert Multiexponential Biomodeling over the Internet. Computer Methods and Programs in Biomedicine.79:169-178, August 2005

  122. GZ Ferl, A. Wu and JJ DiStefano III. A Predictive Model of Therapeutic Monoclonal Antibody Dynamics and Regulation by the Neonatal Fc Receptor (FcRn). In Press, Annals of Biomedical Engineering, November 2005

  123. S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 2005

  124. S Hori, I Kurland and JJ DiStefano III. "Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells" Submitted to Annals of Biomedical Engineering, August 2005. http://www.springerlink.com/content/u6234212174jr515/

  125. GZ Ferl, V Kenanova, AM Wu and JJ DiStefano III. "A two-tiered physiologically-based model for dually labeled single chain Fv- Fc antibody fragments. Molecular Cancer Therapeutics. 5(6):1550-1558, 2006. http://mct.aacrjournals.org/cgi/content/full/5/6/155


  126. Javier RM and JJ DiStefano III. Modeling the Dynamics of Biocontrol Systems Mechanistically. Proceedings of the 5th IFAC MATHMOD Conference, Vienna, Feb 2006.


  127. S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 83:34-42, July 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007


  128. S Hori, I Kurland and JJ DiStefano III. "Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells. Annals of Biomedical Engineering. 34(5):879-92, 2006. http://www.springerlink.com/content/u6234212174jr515/


  129. GZ Ferl, V Kenanova, AM Wu and JJ DiStefano III. "A two-tiered physiologically-based model for dually labeled single chain Fv- Fc antibody fragments. Molecular Cancer Therapeutics. 5(6):1550-1558, 2006. http://mct.aacrjournals.org/cgi/content/full/5/6/1550


  130. M Eisenberg, M Samuels and JJ DiStefano III, L-T4 "Bioequivalence and Hormone Replacement Studies via Feedback Control Simulations". Thyroid, 16(12): 1-14, Dec 2006 http://www.liebertonline.com/toc/thy/16/12


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CONFERENCE ABSTRACTS

  1. J.H. Dussault, J. J. DiStefano, III, & D. A. Fisher, "Placental Transfer of Thyronines and Thyrotropin in Sheep,'' Program, American Pediatric Society; Society for Pediatric Research, p.72, 1971.

  2. J.J. DiStefano, III, and P. H. Mak, "Quantification of Thyroid Hormone-Binding Protein Relationships in Blood,'' Clinical Research, 21:251, 1973.

  3. J.J. DiStefano, III, K. Wilson, M. Jang, & D. A. Fisher, "Estimation of Thyroid Hormone Secretion, Transport and Disposal Rates and the T4 -T3 Conversion Rate in Man,'' Endocrine Society Mtg. Program Supplement, Endocrinology, 92:A178, 1973.

  4. J.J. DiStefano, III, and P. H. Mak, "Thyroid Hormone-Binding Protein Relationships in Blood,'' Endocrine Society Mtg. Program Supplement, Endocrinology, 92:A244, 1973.

  5. J.J. DiStefano, III, K. Wilson, M. Jang & D. A. Fisher, "Tissue-Plasma Interchange of Triiodothyronine and Thyroxine in Man,'' Program, American Thyroid Assn., p.T-18, 1973.

  6. A. Kojima, J. M. Hershman, M. Azukizawa & J. J. DiStefano, III, "Pituitary-Thyroid Axis in Pregnant Rats,'' Clinical Research, 22:164, 1974.

  7. M. Azukizawa, H. V. Roohk, J. J. DiStefano, III, & J. M. Hershman, "Diurnal Rhythm of Plasma TSH, T3 and T4 Levels in Rats,'' Clinical Research, 23:93A, 1975.

  8. R. Weitzman, J. J. DiStefano, III, C. M. Bennett & D. A. Fisher, "Episodic Release of Vasopressin (AVP) in Response to Osmotic Stimulation,'' Program, Endocrine Society Mtg., Abstract No. 325, p.219, 1976.

  9. J.R. Sowers, A. E. Pekary, J. M. Hershman & J. J. DiStefano, III, "Metabolism of Exogenous Human Chorionic Gonadotropin (HCG) in Man,'' Clinical Research, 25:150A, 1977.

  10. J.J. DiStefano, III, and F. Mori, "Identifiability Analysis and Kinetic Experiment Design: Which Parameters of an Endocrine System Model Can Be Estimated from Which Experiments?'' In Proceedings of the Federation of American Societies for Experimental Biology, pp. 128, April 1977.

  11. M. Jang, and J. J. DiStefano, III, "Estimation from a Three Compartment Model of the Plasma-to-Tissue Transport Rate of 3,3',5'- Triiodothyronine (Reverse T3) in Humans,'' In Proceedings of the 30th Annual Conference on Engineering in Medicine and Biology, 19:81, 1977, abstract p.11.6.

  12. R. Fishburn and J. J. DiStefano, III, "A Simulation Study of Glucose Regulation during Hepatic Failure,'' In Proceedings of the 30th Annual Conference on Engineering in Medicine and Biology, 19:389, 1977, abstract p.2.25.

  13. P. Hagander, K-G. Tranberg, J. Thorell & J. J. DiStefano, III, "The Capability of the 25g IVGTT to Characterize Insulin Release,'' Acta Endocr., 85:1977, suppl. 209.

  14. R.F. Chang and J. J. DiStefano, III, "Biocybernetic Analysis of Sexual Maturation in the Male Rat,'' In Proceedings of the 30th Annual Conference on Engineering in Medicine and Biology, 19:164, 1977, abstract 25.1.

  15. J.J. DiStefano, III, and F. Mori, "Cost/Effective Blood Sampling Schedules for Estimating Thyroid Hormone Metabolism Parameters Accurately,'' Clinical Research, 26:105A, 1978.

  16. K. Honbo, A. J. Van Herle & J. J. DiStefano, III, "Peripheral Metabolism of Thyroglobulin in the Rat,'' Clinical Research, 26:106, 1978.

  17. J.J. DiStefano, III, T. Malone, M. Jang & M. Broutman, "Maximally Accurate Parameters of Iodothyronine Metabolism from Only 5 or 6 Blood Samples: a New and Generally Applicable Approach to Kinetic Studies and Its Demonstration in Rats,'' Endocrinology, suppl. l06:98, #95, 1980.

  18. J.J. DiStefano, III, "Skeletal Muscle is the Largest Pool of Triiodothyronine and the Major Site of Its in Vivo Production from Thyroxine in the Rat,'' Clinical Research, 29:026A, 1981.

  19. J.J. DiStefano, III, "Evidence for the Rat as a Good Animal-Model for Human Thyroid Hormone Distribution and Metabolism,'' Endocrinology, suppl. 109:T-44, 1981.

  20. M. Jang, M. Broutman & J. J. DiStefano, III, "T3, T4 and rT3 Distribution and Metabolism in Obesity and Aging,'' Endocrinology, suppl. 109:T:44, 1981.

  21. A. Taurog, K. Okamura, & J. J. DiStefano, III, "Elevated Serum Levels of T3 without Metabolic Effect in Nutritionally Deficient Rats,'' Endocrinology, suppl. 109:T-2, 1981.

  22. M. Jang and J. J. DiStefano, III, "Production of T3 From T4 Is Increased with Aging in Rats,'' Program, Endocrine Society Meeting, Abstract No. 116, pg. 108, 1982.

  23. M. Jang and J. J. DiStefano, III, "T4 Production Rate (PR) and Total Pool Size Do not Change with Age or Body Weight in Rats,'' Endocrinology, suppl. 111:T-27, 1982.

  24. J.J. DiStefano, III, V. Sapin, D. Harris & R. M. Mizumoto, "Widely Differing Fecal and No Urinary Excretion of Five Iodothyronines in the Rat,'' Program, American Thyroid Association Meeting, supplement to Endocrinology, 113:T63, 1983.

  25. R. Ross, K. Nademanee, B. N. Singh & J. J. DiStefano, III, J. M. Hershman, M. Sugawara, A.E. Pekary, A.W. Reed, Jr., "T4 and T3 Kinetics in Cardiac Patients Taking Amiodarone,'' Endocrinology, suppl. 113:xiv, 1983.

  26. A. Shiroozu, A. Taurog & J. J. DiStefano, III, "Effect of Severe Iodine Deficiency on Kinetic Parameters for T4 and T3 in Rats,'' Program, 7th Int'l. Congress of Endocrinology, Quebec, July 1984.

  27. J.J. DiStefano, III, V. Sapin & D. G. Feng, "Comparative Aspects of the Distribution, Metabolism and Excretion of All Outer Ring Labeled Iodothyronines in the Rat,'' Program, 14th Annual Mtg. European Thyroid Assn., p. 59, September 1984; Program, 60th Annual Mtg. American Thyroid Assn., September, 1984; Endocrinology, suppl. 115:T-22.

  28. M. Sternlicht, D. H. Harris & J. J. DiStefano, III, "Enterohepatic Circulation and Systemic Absorption of Thyroid Hormones from Rat Intestine,'' Program, 14th Annual Mtg. European Thyroid Assn., p. 44, September 1984; Program, 60th Annual Mtg. American Thyroid Assn., September, 1984; Endocrinology, suppl. 115:T-45.

  29. M. England., J. M. Hershman, A. E. Pekary, D. G. Feng & J. J. DiStefano, III, "T4 and T3 Kinetics in Patients Taking Sodium Ipodate," Prog., 60th Annual Mtg., American Thyroid Assn., September, 1984; Endocrinology, suppl. 115:T-6.

  30. J.J. DiStefano, III, V. Sapin, S. Sindt, A. Pizzo, H. Rahimizadeh & D. Baghai, "The Luminal Contents of Rat Intestine Contain Large Thyroid Hormone Pools Exchangeable with Hormones in Blood," 69th Mtg. of The Endocrine Society, #125, p.62, June 1986.

  31. B. Chang, J. J. DiStefano, III, K. Roth, E. Gonzales & D. Caswell, "Computer-Assisted Nursing Diagnoses Instrument, (CANDI)," 39th Annual Mtg. of the Gerontological Society of America, November, 1986.

  32. J.J. DiStefano, III & D. Feng, "Distribution, Metabolism and Biliary and Circulatory Fluxes of Thyroid Hormones in Liver, Intestinal Wall, Luminal Contents and Kidney of the Rat," The American Thyroid Assn. Mtg., #85, p. T-43, September 1986.

  33. J.J. DiStefano, III, "Excretion, Metabolism and Enterohepatic Circulation Pathways and Their Role in Overall Thyroid Hormone Regulation in the Rat," The American Zoologist Assn. Mtg., December 1986.

  34. J.J. DiStefano, III, "Optimizing Sampling Schedule Designs for Kinetic Experiments: Conceptual Framework, Software & Practical Experiences", The Pharmacokinetics and Pharmacodynamics, A Meeting of the USC Biomedical Simulation Resource, May 1987.

  35. J.J. DiStefano, III, W. L. Morris, R. Wang & T. Nguyen, "Enterohepatic Regulation & Metabolism of T3 in Hypothyroid Rats," The American Thyroid Assn. Mtg., September 1987.

  36. J.J. DiStefano, III, "Biomodel Formulation and Identification Using Optimal and Other Effective Experiment Designs", First IFAC Symposium on Modelling and Control in Biomedical Systems, Venice, Italy, April 6-8, 1988.

  37. A.E. Pekary, R. L. Stephens, Y. Tache, J. J. DiStefano, III, E. M. Landaw, and J. M. Hershman, "Kinetics of In Vivo TRH-Gly to TRH Conversion in Rat Cerebro-Spinal Fluid", The Endocrine Society Mtg., June 1988.

  38. A. de Luze, T. Nguyen, E. Kim, J.J. DiStefano, III, "Rat Intestinal Microflora Reversibly Bind and Deiodinate 3,5,3'-Triiodothyronine (T3). In proceding at the American Thyroid Association Annual Meeting, Montreal, Canada, #130, p.T-67, September 1988.

  39. A. de Luze, E. Kim, T. Nguyen, J.J. DiStefano, III, "Bacteria-Dependent Deiodination of 3,5,3'-Triiodothyronine (T3) in Rat Fecal Homogenate", The American Zoologists Annual Meeting, San Francisco, California, T-38: 74, December 1988.

  40. J.J. DiStefano, III, T. Nguyen, Y-M. Yen, E. Kim, "Absorption & Arterial Reflux of T3 & T4 From and to Rat Intestines in vivo", The American Thyroid Assn. Mtg., San Francisco, CA, T-66: 131, September 1989.

  41. A. de Luze, E. Kim, T. Nguyen, J.J. DiStefano, III, "Inner-Ring-(5), but not 5'-Deiodination, of T3 occurs in the Intestinal Contents of Bacteria Decontaminated Rats", The American Thyroid Asssociation Meeting, San Francisco, California, T-38: 74, September 1989.

  42. J.J. DiStefano, III, T.T. Nguyen, Y-M. Yen, A. King, A. Saadat, L-M. Huang, "Biliary Fluxes & Relative Uptake Dynamics of T4 & T3 From Blood to Rat Intestines, Liver & Kidneys In Vivo", In Proceedings of the International Thyroid Association Meeting, The Hague, The Netherlands, pp. 11-4, February 3-8, 1991.

  43. J.J. DiStefano, III, T. Nguyen, B. Ron, Y-M. Yen, G. Weber, G. Grau, "Fish vs. Rat Triiodothyronine T3) & Thyroxine (T4) Uptake Rates in Liver, Kidneys & Intestines: Evidence for Different Liver Uptake Mechanisms", The American Thyroid Association Meeting, S-40:80, Boston, September 12-15, 1991.

  44. B. Ron, J.J. DiStefano, III, T. Nguyen, H. Yamada, D. Okimoto, G. Weber, H. Richman, G. Grau, "Triiodothyronine Kinetics in the Fresh Water Male Tilapia, Oreochromis Mossambiscus", In Proceeding in the World Aquacultural Society, Orlando, Florida, May 26-29, 1992.

  45. T.T. Nguyen, L-M. Huang, H. Yamada, J.J. DiStefano, III, H.J. Cahnmann, "Evidence for 5-D and 5'-D Activities in Adult Rat Intestinal Contents, Inhibited by Intestinal Microflora", In Proceeding in the 66th American Thyroid Association Meeting, S-59:93, Rochester, Minnesota, September 23-26, 1992.

  46. Y-M. Yen, H. Yamada, J.J. DiStefano, III, and T.T. Nguyen. "Whole-Body Thyroid Hormone Pools, Interconversion Rates and "Hidden" T3 Pools in Fed and Fasted Rats: Hormone Regulation Implications", Presented at the Endocrine Society Mtg, June 1993, Abstract #829 pg. 258.

  47. T.T. Nguyen, J.J. DiStefano, III, H. Yamada, "Differential Steady state organ distribution & metabolism of thyroxine (T4) & 3,4,3'- triiodothyronine (T3) in intestines, liver, kidneys, blood & residual carcass of the rat in vivo", In Proceeding in the 67th American Thyroid Association Meeting, T-56:110, Tampa, Florida, November 10-14, 1993.

  48. H. Yamada, Y-M Yen, T. Nguyen, J.J. DiStefano, III, "Hierarchical regulation of T4 to T3 interconversion and whole-body T3 and T4 pool sizes in hypo- and mildly T3 hyperthyroid rats. In Proceeding in the 67th American Thyroid Association Meeting, T-54:106, Tampa, Florida, November 10-14, 1993.

  49. J. Mordenti, T. Nguyen, D. Eastman, G. Osaka, S. Frie, R. Weissburg, P. Berman, P. Abramowitz, J.J. DiStefano, III and M. Powell, "Effect of alum on im absorption and immunogenicity of mn gp120 in rabbits". In Proceeding in the American Association of Pharmaceutical Scientists Meeting, San Francisco, March 24-25, 1994.

  50. J.J. DiStefano, III, P. Waechter, P. Abramowitz, H-T Su and T.T. Nguyen, "Expert System-Knowledge Based Biomodeling", IFAC Symposium on Modeling & Control in Biomedical System, Galveston, Texas, March 27-30, 1994.

  51. J.J. DiStefano, III, N. Brown and M. Patterson, "Multilevel Control of Hormone Action", In Proceeding of the Biomedical Engineering Society Meeting in Boston, October 6-8, 1995.

  52. T.T. Nguyen, S. Hakimian and J.J. DiStefano, III, "Topologies For Identification Local Organ Hormone Control Mechanisms", In Proceeding of the Biomedical Engineering Society Meeting in Boston, October 6-8, 1995.

  53. J.J. DiStefano, III, T.T. Nguyen, A. Poon, E.Silva, "T3 Production Pathways, Organ Exchange & Distribution Kinetics in Hypothyroid Rats Revisited: Type II 5'-Deiodinase (D2) & Enhanced Slow Pool T3 Sources and Uptake", In Proceeding of the American Thyroid Association 69th Meeting in San Diego, November 14-17, 1996.

  54. T.T. Nguyen, J. Buciak, T. Tuong, P. Kim, K. Shoghi-Jadid, E. Evangelista, J.J. DiStefano, III, "Direct Measurement of the Contribution of Type II 5'-Deiodinase (D2) to Steady State Whole-Body T3 Production from T4 in the Rat", In Proceeding of the American Thyroid Association 69th Meeting in San Diego, November 14-17, 1996.

  55. T.T. Nguyen T.T., K. Mol, H. Tran, J.J. DiStefano, III, "Adult Rat Brain+Pituitary Contribute < 2% to Whole-Body Triiodothyronine (T3) Production from Thyroxine (T4)", In Proceeding of the 70th American Thyroid Association Meeting in Colorado Springs, October 14-19, 1997.

  56. T.T. Nguyen T.T., K. Mol, H., J.J. DiStefano, III, "Adult Rat Enterohepatic Organs (Intestine and Liver) Contribute About a Third to Whole-Body Triiodothyronine (T3) Production from Thyroxine (T4)", In Proceeding of the 71st American Thyroid Association Meeting, Portland, 1998.

  57. K. Mol, T.T. Nguyen, J.J. DiStefano, III, "Adult Rat Kidneys Contribute 9.3% to Whole-Body Triiodothyronine (T3) Production from Thyroxine (T4)", In Proceeding of the 71st American Thyroid Association Meeting, Portland, 1998.

  58. K. Mol, T.T. Nguyen, J.J. DiStefano, III, "Kidney 5'-Deiodination Contributes About 15% To Whole-Body Conversion Of Thyroxine (T4) To Triiodothyronine (T3) In Normal Adult Rats In Vivo." In Proceeding of the 72nd American Thyroid Association Meeting, West Palm Beach, FL 1999.

  59. T.T. Nguyen, K. Mol and J.J. DiStefano, III. "Brain Update: Adult Rat Brain + Pituitary Contribute At Least 7% To Whole-Body Triiodothyronine (T3) Production From Thyroxine (T4)". In Proceeding of the 72nd American Thyroid Association Meeting, West Palm Beach, FL 1999.

  60. J.J. DiStefano, III "Whole-Body And Organ-Specific Thyroid Hormone Production In Vivo." In Proceedings of the International Symposium on Thyroid Hormone Metabolism, Taiwan, Oct 2000.

  61. J.J. DiStefano, III & Adrienne Chen. "Central, Organ-Level & Cellular Thyroid Hormone Regulation Dynamics: Normal & "Dynamic Disease" Behavior, Including Oscillations & Chaos." In Proceedings of the 72nd American Thyroid Association Meeting, 2001.

  62. S. Pallud, Kelly R., DiStefano J.J. III, Parlow A.F., Galton V.A., StGermain D. "Metabolic Effect of Targeted Expression of Type 2 Iodothyroinine Deiodinase to Rodent Liver". In Procs of the 73rd American Thyroid Association Meeting, 2002.

  63. Ferl, G.Z. and DiStefano, J.J. III. "FcRn-Mediated IgG Kinetics: Parameterization of an FcRn Submodel Within a Physiologically-Based Pharmacokinetic Model". In Proceedings of the Symposium on Digital Biology: The Emerging Paradigm, NIH Biomedical Information Science and Technology Initiative Consortium (BISTIC), NIH, Bethesda MD, Nov 6 and 7, 2003.

  64. M Eisenberg, M Samuels and JJ DiStefano III, L-T4 "Bioequivalence and Hormone Replacement Studies via Feedback Control Simulations". Thyroid, 16(12): 1-14, Dec 2006
    http://www.liebertonline.com/toc/thy/16/12

  65. GZ Ferl, V Kenanova, AM Wu and JJ DiStefano III. "A two-tiered physiologically-based model for dually labeled single chain Fv- Fc antibody fragments. Molecular Cancer Therapeutics. 5(6):1550-1558, 2006.
    http://mct.aacrjournals.org/cgi/content/full/5/6/1550

  66. S Hori, I Kurland and JJ DiStefano III. "Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells. Annals of Biomedical Engineering. 34(5):879-92, 2006.
    http://www.springerlink.com/content/u6234212174jr515/

  67. S Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine. 83(1): 34-42, 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007

  68. Javier RM and JJ DiStefano III. Modeling the Dynamics of Biocontrol Systems Mechanistically. Proceedings of the 5th IFAC MATHMOD Conference, Vienna, Feb 2006.

  69. S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 83:34-42, July 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007
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OTHER LABORATORY PUBLICATIONS

  1. Fox, J., Brown, N. "Sensitivity and Consistency of Affymetrix GeneChip Normalization Methods." Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, Massachusetts, USA; 14–17 October 2007: p 1081-1086. 2007.

  2. Fox, J., Brown, N. "Automatically Extracting Acronyms from Biomedical Text." Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, Massachusetts, USA; 14–17 October 2007: p 1245-1248. 2007.

  3. Fox, J., Brown, N. "Data Dependencies in the Quantitation of Affymetrix Gene Expression Data." Proceedings of the WCECS International Conference on Computational Biology. San Francisco, California, USA; 24-26 October, 2007: p 29-33. 2007.

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LABORATORY SPECIAL REPORTS

  1. J.J. DiStefano, III, "Cost/Effective Design of Kinetic Experiments in Physiology,'' Biocybernetics Lab. Report R77-1, School of Engineering and Applied Science, UCLA, January 1976.

  2. J.J. DiStefano, III, and F. Mori, "Identifiability Analysis and Kinetic Experiment Design: an Endocrine System Case Study - Parameters of Thyroid Hormone Metabolism,'' Biocybernetics Lab. Report 76-2, UCLA-ENG- 7636, School of Engineering and Applied Science, UCLA, February 1976.

  3. J.J. DiStefano, III, "Theory, Measurement and Computation of Clearance Rates of Hormones and Other Substances in Biological Systems, Part I - Clearance Rate Concepts and Properties,'' Biocybernetics Lab. Report 76- 3, UCLA-ENG-7637, School of Engineering and Applied Science, UCLA, March 1976.

  4. P-O. Gutman and J. J. DiStefano, III, "Parameters of Iodothyronine Metabolism (T3 , T4 , rT3) from Normal and Pathologic Human Data: Some Numerical Results Concerning Parameter Estimates, Their Variability and Their Possible Utility in Diagnostic Classification,'' Biocybernetics Lab. Report 77-1, UCLA-ENG-7730, School of Engineering and Applied Science, UCLA, April 1977.

  5. R. Fishburn and J. J. DiStefano, III, "A FORTRAN Program for Plasma (Metabolic) Clearance Rate Computations: Conversational Version 1,'' Biocybernetics Lab. Report 77-2, UCLA-ENG-7758, School of Engineering and Applied Science, UCLA, July 1977.

  6. J.J. DiStefano, III and L. A. Campfield, "Biocybernetics Laboratory Research and Academic Program", Biocybernetics Laboratory. Activity Report 77-3, School of Engineering and Applied Science, UCLA, July 1977.

  7. R. Aaslid, J. J. DiStefano, III, & J. G. Balchen, "Modeling of the Hormonal State of Fishes,'' Division of Engineering Cybernetics, Report A76081, The Norwegian Institute of Technology, The University of Trondheim, Norway, 1977.

  8. R. Fishburn, J. J. DiStefano, III, L. A. Campfield & G. L. Gitnick, "Pilot Studies for an On-Line Glucose Measurement System and Automatic Glucose Controller for Treatment of Acute Liver Failure,'' Biocybernetics Lab. Report 78-1, UCLA-ENG-7832, School of Engineering and Applied Science, UCLA, June 1978.
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