STUDY VERS_1.1.0 MODEL COMPDEF CALCINTS 150 MAXITER 20 ABS_DATAWT 1 MDL_VARIANCE 0 INTGRTR Rosenbrock INTGRTR_ERR_ON 1 INTGRTR_ERR 1.00000000e-003 USE_FWD_DERIV 0 CONV_CRIT 1.00000000e-006 LAMBDA 1.00000000e+001 COMPART 44 REF endo_f EXPER MODEL XCOORD 916 YCOORD 372 COMPART q44 REF endo_f EXPER tracer XCOORD 916 YCOORD 372 COMPART 27 REF endo_b EXPER MODEL XCOORD 983 YCOORD 302 COMPART q27 REF endo_b EXPER tracer XCOORD 983 YCOORD 302 COMPART 17 REF endo_f EXPER MODEL XCOORD 325 YCOORD 480 COMPART q17 REF endo_f EXPER tracer XCOORD 325 YCOORD 480 COMPART 7 REF endo_b EXPER MODEL XCOORD 324 YCOORD 379 COMPART q7 REF endo_b EXPER tracer XCOORD 324 YCOORD 379 COMPART 43 REF v_Heart EXPER MODEL XCOORD 1175 YCOORD 501 COMPART q43 REF v_Heart EXPER tracer XCOORD 1175 YCOORD 501 COMPART 42 REF v_Lung EXPER MODEL XCOORD 339 YCOORD 722 COMPART q42 REF v_Lung EXPER tracer XCOORD 339 YCOORD 722 COMPART 41 REF v_Liver EXPER MODEL XCOORD 1506 YCOORD 508 COMPART q41 REF v_Liver EXPER tracer XCOORD 1506 YCOORD 508 COMPART 40 REF v_Bone EXPER MODEL XCOORD 609 YCOORD 485 COMPART q40 REF v_Bone EXPER tracer XCOORD 609 YCOORD 485 COMPART 39 REF v_Muscle EXPER MODEL XCOORD 419 YCOORD 480 COMPART q39 REF v_Muscle EXPER tracer XCOORD 419 YCOORD 480 COMPART 38 REF v_Skin EXPER MODEL XCOORD 983 YCOORD 494 COMPART q38 REF v_Skin EXPER tracer XCOORD 983 YCOORD 494 COMPART 37 REF v_Kidney EXPER MODEL XCOORD 793 YCOORD 423 COMPART q37 REF v_Kidney EXPER tracer XCOORD 793 YCOORD 423 COMPART 36 REF v_Tumor EXPER MODEL XCOORD 133 YCOORD 501 COMPART q36 REF v_Tumor EXPER tracer XCOORD 133 YCOORD 501 FFEQ q36.FF = COMPART 35 REF v_Spleen EXPER MODEL XCOORD 1459 YCOORD 740 COMPART q35 REF v_Spleen EXPER tracer XCOORD 1459 YCOORD 740 COMPART 34 REF v_GI tract EXPER MODEL XCOORD 1787 YCOORD 763 COMPART q34 REF v_GI tract EXPER tracer XCOORD 1787 YCOORD 763 COMPART 33 REF f_Kidney EXPER MODEL XCOORD 834 YCOORD 211 COMPART q33 REF f_Kidney EXPER tracer XCOORD 834 YCOORD 211 COMPART 32 REF B_Kidney EXPER MODEL XCOORD 925 YCOORD 211 COMPART q32 REF B_Kidney EXPER tracer XCOORD 925 YCOORD 211 COMPART 11 REF B_Liver EXPER MODEL XCOORD 1559 YCOORD 405 COMPART q11 REF B_Liver EXPER tracer XCOORD 1559 YCOORD 405 COMPART 30 REF b_Bone EXPER MODEL XCOORD 604 YCOORD 302 COMPART q30 REF b_Bone EXPER tracer XCOORD 604 YCOORD 302 COMPART 29 REF b_Muscle EXPER MODEL XCOORD 417 YCOORD 300 COMPART q29 REF b_Muscle EXPER tracer XCOORD 417 YCOORD 300 COMPART 28 REF b_Skin EXPER MODEL XCOORD 1058 YCOORD 304 COMPART q28 REF b_Skin EXPER tracer XCOORD 1058 YCOORD 304 COMPART 26 REF b_Tumor EXPER MODEL XCOORD 87 YCOORD 302 COMPART q26 REF b_Tumor EXPER tracer XCOORD 87 YCOORD 302 COMPART 25 REF b_Spleen EXPER MODEL XCOORD 1566 YCOORD 646 COMPART q25 REF b_Spleen EXPER tracer XCOORD 1566 YCOORD 646 COMPART 24 REF b_GI tract EXPER MODEL XCOORD 1889 YCOORD 868 COMPART q24 REF b_GI tract EXPER tracer XCOORD 1889 YCOORD 868 COMPART 23 REF b_Heart EXPER MODEL XCOORD 1253 YCOORD 314 COMPART q23 REF b_Heart EXPER tracer XCOORD 1253 YCOORD 314 COMPART 22 REF b_Lung EXPER MODEL XCOORD 233 YCOORD 824 COMPART q22 REF b_Lung EXPER tracer XCOORD 233 YCOORD 824 COMPART 21 REF b_Liver EXPER MODEL XCOORD 1459 YCOORD 304 COMPART q21 REF b_Liver EXPER tracer XCOORD 1459 YCOORD 304 COMPART 20 REF B_Bone EXPER MODEL XCOORD 691 YCOORD 391 COMPART q20 REF B_Bone EXPER tracer XCOORD 691 YCOORD 391 COMPART 19 REF B_Muscle EXPER MODEL XCOORD 513 YCOORD 386 COMPART q19 REF B_Muscle EXPER tracer XCOORD 513 YCOORD 386 COMPART 18 REF B_Skin EXPER MODEL XCOORD 1150 YCOORD 403 COMPART q18 REF B_Skin EXPER tracer XCOORD 1150 YCOORD 403 COMPART 16 REF B_Tumor EXPER MODEL XCOORD 171 YCOORD 393 COMPART q16 REF B_Tumor EXPER tracer XCOORD 171 YCOORD 393 COMPART 15 REF B_Spleen EXPER MODEL XCOORD 1667 YCOORD 742 COMPART q15 REF B_Spleen EXPER tracer XCOORD 1667 YCOORD 742 COMPART 14 REF B_GI tract EXPER MODEL XCOORD 1790 YCOORD 970 COMPART q14 REF B_GI tract EXPER tracer XCOORD 1790 YCOORD 970 COMPART 13 REF B_Heart EXPER MODEL XCOORD 1358 YCOORD 405 COMPART q13 REF B_Heart EXPER tracer XCOORD 1358 YCOORD 405 COMPART 12 REF B_Lung EXPER MODEL XCOORD 340 YCOORD 937 COMPART q12 REF B_Lung EXPER tracer XCOORD 340 YCOORD 937 COMPART q51 REF f_Liver EXPER tracer XCOORD 1459 YCOORD 405 COMPART q2 REF f_Lung EXPER tracer XCOORD 340 YCOORD 824 FFEQ q2.FF = COMPART q3 REF f_Heart EXPER tracer XCOORD 1236 YCOORD 408 COMPART q4 REF f_GI tract EXPER tracer XCOORD 1788 YCOORD 866 COMPART q5 REF f_Spleen EXPER tracer XCOORD 1566 YCOORD 742 COMPART q6 REF f_Tumor EXPER tracer XCOORD 87 YCOORD 393 COMPART q1 REF PLASMA EXPER tracer XCOORD 978 YCOORD 934 COMPART q8 REF f_Skin EXPER tracer XCOORD 1054 YCOORD 398 COMPART q9 REF f_Muscle EXPER tracer XCOORD 419 YCOORD 386 COMPART q10 REF f_Bone EXPER tracer XCOORD 606 YCOORD 389 COMPART q31 REF b_Kidney EXPER tracer XCOORD 836 YCOORD 124 COMPART 31 REF b_Kidney EXPER MODEL XCOORD 836 YCOORD 124 COMPART 10 REF f_Bone EXPER MODEL XCOORD 606 YCOORD 389 COMPART 9 REF f_Muscle EXPER MODEL XCOORD 419 YCOORD 386 COMPART 8 REF f_Skin EXPER MODEL XCOORD 1054 YCOORD 398 COMPART 1 REF PLASMA EXPER MODEL XCOORD 978 YCOORD 934 COMPART 6 REF f_Tumor EXPER MODEL XCOORD 87 YCOORD 393 COMPART 5 REF f_Spleen EXPER MODEL XCOORD 1566 YCOORD 742 COMPART 4 REF f_GI tract EXPER MODEL XCOORD 1788 YCOORD 866 COMPART 3 REF f_Heart EXPER MODEL XCOORD 1236 YCOORD 408 COMPART 2 REF f_Lung EXPER MODEL XCOORD 340 YCOORD 824 COMPART 51 REF f_Liver EXPER MODEL XCOORD 1459 YCOORD 405 XFER k(38,27) EXPER MODEL FROM 27 TO 38 XFER k(38,27) UNITS mass/time EXPER tracer FROM q27 TO q38 EQ flux(38,27) = k(38,27) * q27 EQ k(38,27) = k_rec_IgG XFER k(44,38) EXPER MODEL FROM 38 TO 44 XFER k(44,38) UNITS mass/time EXPER tracer FROM q38 TO q44 EQ flux(44,38) = k(44,38) * q38 EQ k(44,38) = k_int_IgG XFER k(27,44) EXPER MODEL FROM 44 TO 27 XFER k(27,44) UNITS mass/time EXPER tracer FROM q44 TO q27 EQ flux(27,44) = k(27,44) * q44 EQ k(27,44) = k_on_IgG * (FcRn_free - q27) XFER k(44,27) EXPER MODEL FROM 27 TO 44 XFER k(44,27) UNITS mass/time EXPER tracer FROM q27 TO q44 EQ flux(44,27) = k(44,27) * q27 EQ k(44,27) = k_off_IgG XFER k(39,7) EXPER MODEL FROM 7 TO 39 XFER k(39,7) UNITS mass/time EXPER tracer FROM q7 TO q39 EQ flux(39,7) = k(39,7) * q7 EQ k(39,7) = k_rec_IgG XFER k(17,39) EXPER MODEL FROM 39 TO 17 XFER k(17,39) UNITS mass/time EXPER tracer FROM q39 TO q17 EQ flux(17,39) = k(17,39) * q39 EQ k(17,39) = k_int_IgG XFER k(17,7) EXPER MODEL FROM 7 TO 17 XFER k(17,7) UNITS mass/time EXPER tracer FROM q7 TO q17 EQ flux(17,7) = k(17,7) * q7 EQ k(17,7) = k_off_IgG XFER k(7,17) EXPER MODEL FROM 17 TO 7 XFER k(7,17) UNITS mass/time EXPER tracer FROM q17 TO q7 EQ flux(7,17) = k(7,17) * q17 EQ k(7,17) = k_on_IgG * (FcRn_free - q7) XFER k(41,34) EXPER MODEL FROM 34 TO 41 XFER k(41,34) UNITS mass/time EXPER tracer FROM q34 TO q41 EQ flux(41,34) = k(41,34) * q34 EQ k(41,34) = (Q_gi - L_gi) / Vv_gi XFER k(41,35) EXPER MODEL FROM 35 TO 41 XFER k(41,35) UNITS mass/time EXPER tracer FROM q35 TO q41 EQ flux(41,35) = k(41,35) * q35 EQ k(41,35) = (Q_spleen - L_spleen) / Vv_spleen XFER k(42,41) EXPER MODEL FROM 41 TO 42 XFER k(42,41) UNITS mass/time EXPER tracer FROM q41 TO q42 EQ flux(42,41) = k(42,41) * q41 EQ k(42,41) = (Q_liver - L_liver) / Vv_liver XFER k(42,43) EXPER MODEL FROM 43 TO 42 XFER k(42,43) UNITS mass/time EXPER tracer FROM q43 TO q42 EQ flux(42,43) = k(42,43) * q43 EQ k(42,43) = (Q_heart - L_heart) / Vv_heart XFER k(42,38) EXPER MODEL FROM 38 TO 42 XFER k(42,38) UNITS mass/time EXPER tracer FROM q38 TO q42 EQ flux(42,38) = k(42,38) * q38 EQ k(42,38) = (Q_skin - L_skin) / Vv_skin XFER k(42,37) EXPER MODEL FROM 37 TO 42 XFER k(42,37) UNITS mass/time EXPER tracer FROM q37 TO q42 EQ flux(42,37) = k(42,37) * q37 EQ k(42,37) = (Q_kidney - L_kidney) / Vv_kidney XFER k(42,40) EXPER MODEL FROM 40 TO 42 XFER k(42,40) UNITS mass/time EXPER tracer FROM q40 TO q42 EQ flux(42,40) = k(42,40) * q40 EQ k(42,40) = (Q_bone - L_bone) / Vv_bone XFER k(42,39) EXPER MODEL FROM 39 TO 42 XFER k(42,39) UNITS mass/time EXPER tracer FROM q39 TO q42 EQ flux(42,39) = k(42,39) * q39 EQ k(42,39) = (Q_muscle - L_muscle) / Vv_muscle XFER k(42,36) EXPER MODEL FROM 36 TO 42 XFER k(42,36) UNITS mass/time EXPER tracer FROM q36 TO q42 EQ flux(42,36) = k(42,36) * q36 EQ k(42,36) = (Q_tumor - L_tumor) / Vv_tumor XFER k(1,42) EXPER MODEL FROM 42 TO 1 XFER k(1,42) UNITS mass/time EXPER tracer FROM q42 TO q1 EQ flux(1,42) = k(1,42) * q42 EQ k(1,42) = (Q_Lung - L_lung)/Vv_lung XFER k(43,1) EXPER MODEL FROM 1 TO 43 XFER k(43,1) UNITS mass/time EXPER tracer FROM q1 TO q43 EQ flux(43,1)=k(43,1)*q1 EQ k(43,1)=Q_heart/V_plasma XFER k(35,1) EXPER MODEL FROM 1 TO 35 XFER k(35,1) UNITS mass/time EXPER tracer FROM q1 TO q35 EQ flux(35,1)=k(35,1)*q1 EQ k(35,1)=Q_spleen/V_plasma XFER k(41,1) EXPER MODEL FROM 1 TO 41 XFER k(41,1) UNITS mass/time EXPER tracer FROM q1 TO q41 EQ flux(41,1)=k(41,1)*q1 EQ k(41,1)=(Q_liver - Q_gi - Q_spleen + L_gi + L_spleen)/V_plasma XFER k(34,1) EXPER MODEL FROM 1 TO 34 XFER k(34,1) UNITS mass/time EXPER tracer FROM q1 TO q34 EQ flux(34,1)=k(34,1)*q1 EQ k(34,1)=Q_gi/V_plasma XFER k(38,1) EXPER MODEL FROM 1 TO 38 XFER k(38,1) UNITS mass/time EXPER tracer FROM q1 TO q38 EQ flux(38,1)=k(38,1)*q1 EQ k(38,1)=Q_skin/V_plasma XFER k(37,1) EXPER MODEL FROM 1 TO 37 XFER k(37,1) UNITS mass/time EXPER tracer FROM q1 TO q37 EQ flux(37,1)=k(37,1)*q1 EQ k(37,1)=Q_kidney/V_plasma XFER k(40,1) EXPER MODEL FROM 1 TO 40 XFER k(40,1) UNITS mass/time EXPER tracer FROM q1 TO q40 EQ flux(40,1)=k(40,1)*q1 EQ k(40,1)=Q_bone/V_plasma XFER k(39,1) EXPER MODEL FROM 1 TO 39 XFER k(39,1) UNITS mass/time EXPER tracer FROM q1 TO q39 EQ flux(39,1)=k(39,1)*q1 EQ k(39,1)=Q_muscle/V_plasma XFER k(33,37) EXPER MODEL FROM 37 TO 33 XFER k(33,37) UNITS mass/time EXPER tracer FROM q37 TO q33 EQ flux(33,37) = k(33,37) * q37 EQ k(33,37) = (J_L_kidney * (1 - sigma_a_L) * (1 / Vv_kidney) + PS_L_kidney * ((1 / Vv_kidney) - (q33/Vi_kidney) / (q37*R_kidney)) * Pe_a_L_kidney / (exp(Pe_a_L_kidney) - 1) + J_S_kidney * (1 - sigma_a_S) * (1 / Vv_kidney)+PS_S_kidney * ((1 / Vv_kidney) - (q33/Vi_kidney) / (q37*R_kidney)) * Pe_a_S_kidney / (exp(Pe_a_S_kidney) - 1)) XFER k(2,42) EXPER MODEL FROM 42 TO 2 XFER k(2,42) UNITS mass/time EXPER tracer FROM q42 TO q2 EQ flux(2,42) = k(2,42) * q42 EQ k(2,42) = (J_L_lung * (1 - sigma_a_L) * (1 / Vv_lung) + PS_L_lung * ((1 / Vv_lung) - (q2/Vi_lung) / (q42*R_lung)) * Pe_a_L_lung / (exp(Pe_a_L_lung) - 1) + J_S_lung * (1 - sigma_a_S) * (1 / Vv_lung)+PS_S_lung * ((1 / Vv_lung) - (q2/Vi_lung) / (q42*R_lung)) * Pe_a_S_lung / (exp(Pe_a_S_lung) - 1)) XFER k(36,1) EXPER MODEL FROM 1 TO 36 XFER k(36,1) UNITS mass/time EXPER tracer FROM q1 TO q36 EQ flux(36,1)=k(36,1)*q1 EQ k(36,1)=Q_tumor/V_plasma XFER k(6,36) EXPER MODEL FROM 36 TO 6 XFER k(6,36) UNITS mass/time EXPER tracer FROM q36 TO q6 EQ flux(6,36) = k(6,36) * q36 EQ k(6,36) = (J_L_tumor * (1 - sigma_a_L) * (1 / Vv_tumor) + PS_L_tumor * ((1 / Vv_tumor) - (q6/Vi_tumor) / (q36*R_tumor)) * Pe_a_L_tumor / (exp(Pe_a_L_tumor) - 1) + J_S_tumor * (1 - sigma_a_S) * (1 / Vv_tumor)+PS_S_tumor * ((1 / Vv_tumor) - (q6/Vi_tumor) / (q36*R_tumor)) * Pe_a_S_tumor / (exp(Pe_a_S_tumor) - 1)) XFER k(9,39) EXPER MODEL FROM 39 TO 9 XFER k(9,39) UNITS mass/time EXPER tracer FROM q39 TO q9 EQ flux(9,39) = k(9,39) * q39 EQ k(9,39) = (J_L_muscle * (1 - sigma_a_L) * (1 / Vv_muscle) + PS_L_muscle * ((1 / Vv_muscle) - (q9/Vi_muscle) / (q39*R_muscle)) * Pe_a_L_muscle / (exp(Pe_a_L_muscle) - 1) + J_S_muscle * (1 - sigma_a_S) * (1 / Vv_muscle)+PS_S_muscle * ((1 / Vv_muscle) - (q9/Vi_muscle) / (q39*R_muscle)) * Pe_a_S_muscle / (exp(Pe_a_S_muscle) - 1)) XFER k(10,40) EXPER MODEL FROM 40 TO 10 XFER k(10,40) UNITS mass/time EXPER tracer FROM q40 TO q10 EQ flux(10,40) = k(10,40) * q40 EQ k(10,40) = (J_L_bone * (1 - sigma_a_L) * (1 / Vv_bone) + PS_L_bone * ((1 / Vv_bone) - (q10/Vi_bone) / (q40*R_bone)) * Pe_a_L_bone / (exp(Pe_a_L_bone) - 1) + J_S_bone * (1 - sigma_a_S) * (1 / Vv_bone)+PS_S_bone * ((1 / Vv_bone) - (q10/Vi_bone) / (q40*R_bone)) * Pe_a_S_bone / (exp(Pe_a_S_bone) - 1)) XFER k(8,38) EXPER MODEL FROM 38 TO 8 XFER k(8,38) UNITS mass/time EXPER tracer FROM q38 TO q8 EQ flux(8,38) = k(8,38) * q38 EQ k(8,38) = (J_L_skin * (1 - sigma_a_L) * (1 / Vv_skin) + PS_L_skin * ((1 / Vv_skin) - (q8/Vi_skin) / (q38*R_skin)) * Pe_a_L_skin / (exp(Pe_a_L_skin) - 1) + J_S_skin * (1 - sigma_a_S) * (1 / Vv_skin)+PS_S_skin * ((1 / Vv_skin) - (q8/Vi_skin) / (q38*R_skin)) * Pe_a_S_skin / (exp(Pe_a_S_skin) - 1)) XFER k(4,34) EXPER MODEL FROM 34 TO 4 XFER k(4,34) UNITS mass/time EXPER tracer FROM q34 TO q4 EQ flux(4,34) = k(4,34) * q34 EQ k(4,34) = (J_L_gi * (1 - sigma_a_L) * (1 / Vv_gi) + PS_L_gi * ((1 / Vv_gi) - (q4/Vi_gi) / (q34*R_gi)) * Pe_a_L_gi / (exp(Pe_a_L_gi) - 1) + J_S_gi * (1 - sigma_a_S) * (1 / Vv_gi)+PS_S_gi * ((1 / Vv_gi) - (q4/Vi_gi) / (q34*R_gi)) * Pe_a_S_gi / (exp(Pe_a_S_gi) - 1)) XFER k(51,41) EXPER MODEL FROM 41 TO 51 XFER k(51,41) UNITS mass/time EXPER tracer FROM q41 TO q51 EQ flux(51,41)=k(51,41)*q41 EQ k(51,41) = (J_L_liver * (1 - sigma_a_L) * (1 / Vv_liver) + PS_L_liver * ((1 / Vv_liver) - (q41/Vi_liver) / (q36*R_liver)) * Pe_a_L_liver / (exp(Pe_a_L_liver) - 1) + J_S_liver * (1 - sigma_a_S) * (1 / Vv_liver)+PS_S_liver * ((1 / Vv_liver) - (q51/Vi_liver) / (q41*R_liver)) * Pe_a_S_liver / (exp(Pe_a_S_liver) - 1)) XFER k(3,43) EXPER MODEL FROM 43 TO 3 XFER k(3,43) UNITS mass/time EXPER tracer FROM q43 TO q3 EQ flux(3,43) = k(3,43) * q43 EQ k(3,43) = (J_L_heart * (1 - sigma_a_L) * (1 / Vv_heart) + PS_L_heart * ((1 / Vv_heart) - (q3/Vi_heart) / (q43*R_heart)) * Pe_a_L_heart / (exp(Pe_a_L_heart) - 1) + J_S_heart * (1 - sigma_a_S) * (1 / Vv_heart)+PS_S_heart * ((1 / Vv_heart) - (q3/Vi_heart) / (q43*R_heart)) * Pe_a_S_heart / (exp(Pe_a_S_heart) - 1)) XFER k(5,35) EXPER MODEL FROM 35 TO 5 XFER k(5,35) UNITS mass/time EXPER tracer FROM q35 TO q5 EQ flux(5,35) = k(5,35) * q35 EQ k(5,35) = (J_L_spleen * (1 - sigma_a_L) * (1 / Vv_spleen) + PS_L_spleen * ((1 / Vv_spleen) - (q5/Vi_spleen) / (q35*R_spleen)) * Pe_a_L_spleen / (exp(Pe_a_L_spleen) - 1) + J_S_spleen * (1 - sigma_a_S) * (1 / Vv_spleen)+PS_S_spleen * ((1 / Vv_spleen) - (q5/Vi_spleen) / (q35*R_spleen)) * Pe_a_S_spleen / (exp(Pe_a_S_spleen) - 1)) XFER k(1,2) EXPER MODEL FROM 2 TO 1 XFER k(1,2) UNITS mass/time EXPER tracer FROM q2 TO q1 EQ flux(1,2)=k(1,2)*q2 EQ k(1,2)=L_lung/Vi_lung XFER k(1,3) EXPER MODEL FROM 3 TO 1 XFER k(1,3) UNITS mass/time EXPER tracer FROM q3 TO q1 EQ flux(1,3)=k(1,3)*q3 EQ k(1,3)=L_heart/Vi_heart XFER k(1,5) EXPER MODEL FROM 5 TO 1 XFER k(1,5) UNITS mass/time EXPER tracer FROM q5 TO q1 EQ flux(1,5)=k(1,5)*q5 EQ k(1,5)=L_spleen/Vi_spleen XFER k(1,51) EXPER MODEL FROM 51 TO 1 XFER k(1,51) UNITS mass/time EXPER tracer FROM q51 TO q1 EQ flux(1,51)=k(1,51)*q51 EQ k(1,51)=L_liver/Vi_liver XFER k(1,4) EXPER MODEL FROM 4 TO 1 XFER k(1,4) UNITS mass/time EXPER tracer FROM q4 TO q1 EQ flux(1,4)=k(1,4)*q4 EQ k(1,4)=L_gi/Vi_gi XFER k(1,8) EXPER MODEL FROM 8 TO 1 XFER k(1,8) UNITS mass/time EXPER tracer FROM q8 TO q1 EQ flux(1,8)=k(1,8)*q8 EQ k(1,8)=L_skin/Vi_skin XFER k(1,33) EXPER MODEL FROM 33 TO 1 XFER k(1,33) UNITS mass/time EXPER tracer FROM q33 TO q1 EQ flux(1,33)=k(1,33)*q33 EQ k(1,33)=L_kidney/Vi_kidney XFER k(1,10) EXPER MODEL FROM 10 TO 1 XFER k(1,10) UNITS mass/time EXPER tracer FROM q10 TO q1 EQ flux(1,10)=k(1,10)*q10 EQ k(1,10)=L_bone/Vi_bone XFER k(1,9) EXPER MODEL FROM 9 TO 1 XFER k(1,9) UNITS mass/time EXPER tracer FROM q9 TO q1 EQ flux(1,9)=k(1,9)*q9 EQ k(1,9)=L_muscle/Vi_muscle XFER k(1,6) EXPER MODEL FROM 6 TO 1 XFER k(1,6) UNITS mass/time EXPER tracer FROM q6 TO q1 EQ flux(1,6)=k(1,6)*q6 EQ k(1,6)=L_tumor/Vi_tumor XFER k(26,6) EXPER MODEL FROM 6 TO 26 XFER k(26,6) UNITS mass/time EXPER tracer FROM q6 TO q26 EQ flux(26,6) = k(26,6) * q6 EQ k(26,6)=(k_af * 1e12)/Vi_tumor * ((B_max*Vi_tumor)/1000 - q26) XFER k(31,33) EXPER MODEL FROM 33 TO 31 XFER k(31,33) UNITS mass/time EXPER tracer FROM q33 TO q31 EQ flux(31,33) = k(31,33) * q33 XFER k(33,32) EXPER MODEL FROM 32 TO 33 XFER k(33,32) UNITS mass/time EXPER tracer FROM q32 TO q33 EQ flux(33,32) = k(33,32) * q32 EQ k(33,32) = k_ar_kidney XFER k(32,33) EXPER MODEL FROM 33 TO 32 XFER k(32,33) UNITS mass/time EXPER tracer FROM q33 TO q32 EQ flux(32,33) = k(32,33) * q33 EQ k(32,33) = k_af_kidney XFER k(33,31) EXPER MODEL FROM 31 TO 33 XFER k(33,31) UNITS mass/time EXPER tracer FROM q31 TO q33 EQ flux(33,31) = k(33,31) * q31 XFER k(20,10) EXPER MODEL FROM 10 TO 20 XFER k(20,10) UNITS mass/time EXPER tracer FROM q10 TO q20 EQ flux(20,10) = k(20,10) * q10 EQ k(20,10) = k_af_bone XFER k(10,30) EXPER MODEL FROM 30 TO 10 XFER k(10,30) UNITS mass/time EXPER tracer FROM q30 TO q10 EQ flux(10,30) = k(10,30) * q30 XFER k(30,10) EXPER MODEL FROM 10 TO 30 XFER k(30,10) UNITS mass/time EXPER tracer FROM q10 TO q30 EQ flux(30,10) = k(30,10) * q10 XFER k(10,20) EXPER MODEL FROM 20 TO 10 XFER k(10,20) UNITS mass/time EXPER tracer FROM q20 TO q10 EQ flux(10,20) = k(10,20) * q20 EQ k(10,20) = k_ar_bone XFER k(29,9) EXPER MODEL FROM 9 TO 29 XFER k(29,9) UNITS mass/time EXPER tracer FROM q9 TO q29 EQ flux(29,9) = k(29,9) * q9 XFER k(9,19) EXPER MODEL FROM 19 TO 9 XFER k(9,19) UNITS mass/time EXPER tracer FROM q19 TO q9 EQ flux(9,19) = k(9,19) * q19 EQ k(9,19) = k_ar_muscle XFER k(19,9) EXPER MODEL FROM 9 TO 19 XFER k(19,9) UNITS mass/time EXPER tracer FROM q9 TO q19 EQ flux(19,9) = k(19,9) * q9 EQ k(19,9) = k_af_muscle XFER k(9,29) EXPER MODEL FROM 29 TO 9 XFER k(9,29) UNITS mass/time EXPER tracer FROM q29 TO q9 EQ flux(9,29) = k(9,29) * q29 XFER k(28,8) EXPER MODEL FROM 8 TO 28 XFER k(28,8) UNITS mass/time EXPER tracer FROM q8 TO q28 EQ flux(28,8) = k(28,8) * q8 XFER k(8,18) EXPER MODEL FROM 18 TO 8 XFER k(8,18) UNITS mass/time EXPER tracer FROM q18 TO q8 EQ flux(8,18) = k(8,18) * q18 EQ k(8,18) = k_ar_skin XFER k(18,8) EXPER MODEL FROM 8 TO 18 XFER k(18,8) UNITS mass/time EXPER tracer FROM q8 TO q18 EQ flux(18,8) = k(18,8) * q8 EQ k(18,8) = k_af_skin XFER k(8,28) EXPER MODEL FROM 28 TO 8 XFER k(8,28) UNITS mass/time EXPER tracer FROM q28 TO q8 EQ flux(8,28) = k(8,28) * q28 XFER k(6,16) EXPER MODEL FROM 16 TO 6 XFER k(6,16) UNITS mass/time EXPER tracer FROM q16 TO q6 EQ flux(6,16) = k(6,16) * q16 EQ k(6,16) = k_ar_tumor XFER k(16,6) EXPER MODEL FROM 6 TO 16 XFER k(16,6) UNITS mass/time EXPER tracer FROM q6 TO q16 EQ flux(16,6) = k(16,6) * q6 EQ k(16,6) = k_af_tumor XFER k(6,26) EXPER MODEL FROM 26 TO 6 XFER k(6,26) UNITS mass/time EXPER tracer FROM q26 TO q6 EQ flux(6,26) = k(6,26) * q26 EQ k(6,26) = k_ar XFER k(23,3) EXPER MODEL FROM 3 TO 23 XFER k(23,3) UNITS mass/time EXPER tracer FROM q3 TO q23 EQ flux(23,3) = k(23,3) * q3 XFER k(3,13) EXPER MODEL FROM 13 TO 3 XFER k(3,13) UNITS mass/time EXPER tracer FROM q13 TO q3 EQ flux(3,13) = k(3,13) * q13 EQ k(3,13) = k_ar_heart XFER k(13,3) EXPER MODEL FROM 3 TO 13 XFER k(13,3) UNITS mass/time EXPER tracer FROM q3 TO q13 EQ flux(13,3) = k(13,3) * q3 EQ k(13,3) = k_af_heart XFER k(3,23) EXPER MODEL FROM 23 TO 3 XFER k(3,23) UNITS mass/time EXPER tracer FROM q23 TO q3 EQ flux(3,23) = k(3,23) * q23 XFER k(25,5) EXPER MODEL FROM 5 TO 25 XFER k(25,5) UNITS mass/time EXPER tracer FROM q5 TO q25 EQ flux(25,5) = k(25,5) * q5 XFER k(5,15) EXPER MODEL FROM 15 TO 5 XFER k(5,15) UNITS mass/time EXPER tracer FROM q15 TO q5 EQ flux(5,15) = k(5,15) * q15 EQ k(5,15) = k_ar_spleen XFER k(15,5) EXPER MODEL FROM 5 TO 15 XFER k(15,5) UNITS mass/time EXPER tracer FROM q5 TO q15 EQ flux(15,5) = k(15,5) * q5 EQ k(15,5) = k_af_spleen XFER k(5,25) EXPER MODEL FROM 25 TO 5 XFER k(5,25) UNITS mass/time EXPER tracer FROM q25 TO q5 EQ flux(5,25) = k(5,25) * q25 XFER k(21,51) EXPER MODEL FROM 51 TO 21 XFER k(21,51) UNITS mass/time EXPER tracer FROM q51 TO q21 EQ flux(21,51)=k(21,51)*q51 XFER k(51,11) EXPER MODEL FROM 11 TO 51 XFER k(51,11) UNITS mass/time EXPER tracer FROM q11 TO q51 EQ flux(51,11)=k(51,11)*q11 EQ k(51,11)=k_ar_liver XFER k(11,51) EXPER MODEL FROM 51 TO 11 XFER k(11,51) UNITS mass/time EXPER tracer FROM q51 TO q11 EQ flux(11,51)=k(11,51)*q51 EQ k(11,51)=k_af_liver XFER k(51,21) EXPER MODEL FROM 21 TO 51 XFER k(51,21) UNITS mass/time EXPER tracer FROM q21 TO q51 EQ flux(51,21)=k(51,21)*q21 XFER k(4,14) EXPER MODEL FROM 14 TO 4 XFER k(4,14) UNITS mass/time EXPER tracer FROM q14 TO q4 EQ flux(4,14) = k(4,14) * q14 EQ k(4,14) = k_ar_gi XFER k(24,4) EXPER MODEL FROM 4 TO 24 XFER k(24,4) UNITS mass/time EXPER tracer FROM q4 TO q24 EQ flux(24,4) = k(24,4) * q4 XFER k(14,4) EXPER MODEL FROM 4 TO 14 XFER k(14,4) UNITS mass/time EXPER tracer FROM q4 TO q14 EQ flux(14,4) = k(14,4) * q4 EQ k(14,4) = k_af_gi XFER k(4,24) EXPER MODEL FROM 24 TO 4 XFER k(4,24) UNITS mass/time EXPER tracer FROM q24 TO q4 EQ flux(4,24) = k(4,24) * q24 XFER k(2,22) EXPER MODEL FROM 22 TO 2 XFER k(2,22) UNITS mass/time EXPER tracer FROM q22 TO q2 EQ flux(2,22) = k(2,22) * q22 XFER k(22,2) EXPER MODEL FROM 2 TO 22 XFER k(22,2) UNITS mass/time EXPER tracer FROM q2 TO q22 EQ flux(22,2) = k(22,2) * q2 XFER k(2,12) EXPER MODEL FROM 12 TO 2 XFER k(2,12) UNITS mass/time EXPER tracer FROM q12 TO q2 EQ flux(2,12) = k(2,12) * q12 EQ k(2,12) = k_ar_lung XFER k(12,2) EXPER MODEL FROM 2 TO 12 XFER k(12,2) UNITS mass/time EXPER tracer FROM q2 TO q12 EQ flux(12,2) = k(12,2) * q2 EQ k(12,2) = k_af_lung LOSS k(0,44) EXPER MODEL FROM 44 LOSS k(0,44) UNITS mass/time EXPER tracer FROM q44 EQ flux(0,44) = k(0,44) * q44 EQ k(0,44) = k_deg_IgG LOSS k(0,17) EXPER MODEL FROM 17 LOSS k(0,17) UNITS mass/time EXPER tracer FROM q17 EQ flux(0,17) = k(0,17) * q17 EQ k(0,17) = k_deg_IgG LOSS k(0,37) EXPER MODEL FROM 37 LOSS k(0,37) UNITS mass/time EXPER tracer FROM q37 EQ flux(0,37) = k(0,37) * q37 EQ k(0,37) = U / Vv_kidney SAMPLE s2 XCOORD 183 YCOORD 206 EXPER tracer INCLUDE q36 INCLUDE q26 INCLUDE q16 INCLUDE q6 LINK.TO Tumor EQ s2 = ((q6 + q16 + q26 + q36) * 100) / (9.7e-13 * Mass_tumor) SAMPLE s11 XCOORD 463 YCOORD 923 EXPER tracer INCLUDE q12 INCLUDE q2 INCLUDE q42 INCLUDE q22 LINK.TO Lung EQ s11 = ((q22 + q42 + q2 + q12) * 100) / (9.7e-13 * Mass_lung) SAMPLE s10 XCOORD 1890 YCOORD 684 EXPER tracer INCLUDE q34 INCLUDE q14 INCLUDE q4 INCLUDE q24 EQ s10 = ((q24 +q4 + q14 + q34) * 100) / (9.7e-13 * Mass_gi) SAMPLE s9 XCOORD 1767 YCOORD 600 EXPER tracer INCLUDE q35 INCLUDE q15 INCLUDE q5 INCLUDE q25 LINK.TO Spleen EQ s9 = ((q25 + q5 + q15 + q35) * 100) / (9.7e-13 * Mass_spleen) SAMPLE s8 XCOORD 1592 YCOORD 243 EXPER tracer INCLUDE q41 INCLUDE q11 INCLUDE q51 INCLUDE q21 LINK.TO Liver EQ s8 = ((q21 + q51 + q11 + q41) * 100) / (9.7e-13 * Mass_liver) SAMPLE s7 XCOORD 1393 YCOORD 240 EXPER tracer INCLUDE q43 INCLUDE q13 INCLUDE q3 INCLUDE q23 EQ s7 = ((q23 + q3 + q13 + q43) * 100) / (9.7e-13 * Mass_heart) SAMPLE s6 XCOORD 1102 YCOORD 107 EXPER tracer INCLUDE q27 INCLUDE q44 INCLUDE q38 INCLUDE q18 INCLUDE q8 INCLUDE q28 EQ s6 = ((q28 + q8 + q18 +q38 + q44 + q27) * 100) / (9.7e-13 * Mass_skin) SAMPLE s5 XCOORD 931 YCOORD 109 EXPER tracer INCLUDE q37 INCLUDE q32 INCLUDE q33 INCLUDE q31 LINK.TO Kidney EQ s5 = ((q31 + q33 + q32 + q37) * 100) / (9.7e-13 * Mass_kidney) SAMPLE s4 XCOORD 680 YCOORD 211 EXPER tracer INCLUDE q40 INCLUDE q20 INCLUDE q10 INCLUDE q30 LINK.TO Bone EQ s4 = ((q30 + q10 + q20 + q40) * 100) / (9.7e-13 * Mass_bone) SAMPLE s3 XCOORD 483 YCOORD 125 EXPER tracer INCLUDE q7 INCLUDE q17 INCLUDE q39 INCLUDE q19 INCLUDE q9 INCLUDE q29 EQ s3 = ((q29 + q9 + q19 + q39 + q17 + q7) * 100) / (9.7e-13 * Mass_muscle) SAMPLE s1 XCOORD 1022 YCOORD 1004 EXPER tracer INCLUDE q1 LINK.TO Blood EQ s1 = (q1 * 100) / (9.7e-13 * Mass_plasma) EXOG.IN ex11 XCOORD 306 YCOORD 755 EXPER tracer INCLUDE q42 TRACER BOLUS INIT 9.70000000e-013 I.BEG 0.00000000e+000 EXOG.IN ex10 XCOORD 1754 YCOORD 796 EXPER tracer INCLUDE q34 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex9 XCOORD 1426 YCOORD 773 EXPER tracer INCLUDE q35 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex8 XCOORD 1473 YCOORD 541 EXPER tracer INCLUDE q41 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex7 XCOORD 1142 YCOORD 534 EXPER tracer INCLUDE q43 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex6 XCOORD 950 YCOORD 527 EXPER tracer INCLUDE q38 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex5 XCOORD 760 YCOORD 456 EXPER tracer INCLUDE q37 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex4 XCOORD 576 YCOORD 518 EXPER tracer INCLUDE q40 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex3 XCOORD 386 YCOORD 513 EXPER tracer INCLUDE q39 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex2 XCOORD 100 YCOORD 534 EXPER tracer INCLUDE q36 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXOG.IN ex1 XCOORD 945 YCOORD 967 EXPER tracer INCLUDE q1 TRACER BOLUS INIT 1.00000000e-099 I.BEG 0.00000000e+000 EXPERIMENT MODEL TYPE MODEL SUFFIX 0 EXPERIMENT tracer TYPE EXOGENOUS SUFFIX 0 EVENTLINE t UNITS minutes E.BEG 0.00000000e+000 E.FIN 1.00800000e+004 GLOBL.EQ J_L_liver = J_iso_liver + alpha_L * L_liver GLOBL.EQ J_L_lung = J_iso_lung + alpha_L * L_lung GLOBL.EQ J_L_kidney = J_iso_kidney + alpha_L * L_kidney GLOBL.EQ J_L_gi = J_iso_gi + alpha_L * L_gi GLOBL.EQ J_L_spleen = J_iso_spleen + alpha_L * L_spleen GLOBL.EQ J_L_skin = J_iso_skin + alpha_L * L_skin GLOBL.EQ J_L_muscle = J_iso_muscle + alpha_L * L_muscle GLOBL.EQ J_L_bone = J_iso_bone + alpha_L * L_bone GLOBL.EQ J_L_heart = J_iso_heart + alpha_L * L_heart GLOBL.EQ J_L_tumor = J_iso_tumor + alpha_L * L_tumor GLOBL.EQ J_S_liver = -J_iso_liver + alpha_S * L_liver GLOBL.EQ J_S_lung = -J_iso_lung + alpha_S * L_lung GLOBL.EQ J_S_kidney = -J_iso_kidney + alpha_S * L_kidney GLOBL.EQ J_S_gi = -J_iso_gi + alpha_S * L_gi GLOBL.EQ J_S_spleen = -J_iso_spleen + alpha_S * L_spleen GLOBL.EQ J_S_skin = -J_iso_skin + alpha_S * L_skin GLOBL.EQ J_S_muscle = -J_iso_muscle + alpha_S * L_muscle GLOBL.EQ J_S_bone = -J_iso_bone + alpha_S * L_bone GLOBL.EQ J_S_heart = -J_iso_heart + alpha_S * L_heart GLOBL.EQ J_S_tumor = -J_iso_tumor + alpha_S * L_tumor GLOBL.EQ Pe_a_L_liver = J_L_liver * (1 - sigma_a_L) / PS_L_liver GLOBL.EQ Pe_a_L_lung = J_L_lung * (1 - sigma_a_L) / PS_L_lung GLOBL.EQ Pe_a_L_kidney = J_L_kidney * (1 - sigma_a_L) / PS_L_kidney GLOBL.EQ Pe_a_L_gi = J_L_gi * (1 - sigma_a_L) / PS_L_gi GLOBL.EQ Pe_a_L_spleen = J_L_spleen * (1 - sigma_a_L) / PS_L_spleen GLOBL.EQ Pe_a_L_skin = J_L_skin * (1 - sigma_a_L) / PS_L_skin GLOBL.EQ Pe_a_L_muscle = J_L_muscle * (1 - sigma_a_L) / PS_L_muscle GLOBL.EQ Pe_a_L_bone = J_L_bone * (1 - sigma_a_L) / PS_L_bone GLOBL.EQ Pe_a_L_heart = J_L_heart * (1 - sigma_a_L) / PS_L_heart GLOBL.EQ Pe_a_L_tumor = J_L_tumor * (1 - sigma_a_L) / PS_L_tumor GLOBL.EQ Pe_a_S_liver = J_S_liver * (1 - sigma_a_S) / PS_S_liver GLOBL.EQ Pe_a_S_lung = J_S_lung * (1 - sigma_a_S) / PS_S_lung GLOBL.EQ Pe_a_S_kidney = J_S_kidney * (1 - sigma_a_S) / PS_S_kidney GLOBL.EQ Pe_a_S_gi = J_S_gi * (1 - sigma_a_S) / PS_S_gi GLOBL.EQ Pe_a_S_spleen = J_S_spleen * (1 - sigma_a_S) / PS_S_spleen GLOBL.EQ Pe_a_S_skin = J_S_skin * (1 - sigma_a_S) / PS_S_skin GLOBL.EQ Pe_a_S_muscle = J_S_muscle * (1 - sigma_a_S) / PS_S_muscle GLOBL.EQ Pe_a_S_bone = J_S_bone * (1 - sigma_a_S) / PS_S_bone GLOBL.EQ Pe_a_S_heart = J_S_heart * (1 - sigma_a_S) / PS_S_heart GLOBL.EQ Pe_a_S_tumor = J_S_tumor * (1 - sigma_a_S) / PS_S_tumor GLOBL.EQ Mass_plasma = .774 GLOBL.EQ Mass_bone = 1.5 * 1.5 GLOBL.EQ Mass_heart = .133 GLOBL.EQ Mass_kidney = .298 GLOBL.EQ Mass_liver = .951 GLOBL.EQ Mass_lung = .191 GLOBL.EQ Mass_muscle = 7.924 GLOBL.EQ Mass_skin = 2.94 GLOBL.EQ Mass_spleen = .1 GLOBL.EQ Mass_gi = 3.45 GLOBL.EQ Mass_tumor = 1e-12*t^3 - 1e-8*t^2 + 5e-5*t + 0.1482 GLOBL.EQ Q_Lung = Q_liver - L_liver + Q_kidney - L_kidney + Q_tumor - L_tumor + Q_skin - L_skin + Q_muscle - L_muscle + Q_bone - L_bone + Q_heart - L_heart GLOBL.EQ PS_S_bone = 7.8e-6 * Mass_bone GLOBL.EQ PS_S_gi = 7.8e-6 * Mass_gi GLOBL.EQ PS_S_heart = 7.8e-6 * Mass_heart GLOBL.EQ PS_S_kidney = 7.8e-6 * Mass_kidney GLOBL.EQ PS_S_liver = 7.8e-5 * Mass_liver GLOBL.EQ PS_S_lung = 7.8e-6 * Mass_lung GLOBL.EQ PS_S_muscle = 7.8e-6 * Mass_muscle GLOBL.EQ PS_S_skin = 7.8e-6 * Mass_skin GLOBL.EQ PS_S_spleen = 7.8e-6 * Mass_spleen GLOBL.EQ PS_S_tumor = 7.8e-5 * Mass_tumor GLOBL.EQ PS_L_bone = 2.66e-6 * Mass_bone GLOBL.EQ PS_L_gi = 2.66e-6 * Mass_gi GLOBL.EQ PS_L_heart = 2.66e-6 * Mass_heart GLOBL.EQ PS_L_kidney = 2.66e-6 * Mass_kidney GLOBL.EQ PS_L_liver = 2.66e-5 * Mass_liver GLOBL.EQ PS_L_lung = 2.66e-6 * Mass_lung GLOBL.EQ PS_L_muscle = 2.66e-6 * Mass_muscle GLOBL.EQ PS_L_skin = 2.66e-6 * Mass_skin GLOBL.EQ PS_L_spleen = 2.66e-6 * Mass_spleen GLOBL.EQ PS_L_tumor = 2.66e-5 * Mass_tumor GLOBL.EQ J_iso_tumor = J_iso_tumor_sp * Mass_tumor GLOBL.EQ J_iso_heart = 5.6e-5 * Mass_heart GLOBL.EQ J_iso_kidney = J_iso_kidney_sp * Mass_kidney GLOBL.EQ J_iso_liver = J_iso_liver_sp * Mass_liver GLOBL.EQ J_iso_lung = J_iso_lung_sp * Mass_lung GLOBL.EQ J_iso_muscle = J_iso_muscle_sp * Mass_muscle GLOBL.EQ J_iso_skin = J_iso_skin_sp * Mass_skin GLOBL.EQ J_iso_spleen = J_iso_spleen_sp * Mass_spleen GLOBL.EQ J_iso_gi = 1e-6 * Mass_gi GLOBL.EQ J_iso_bone = J_iso_bone_sp * Mass_bone GLOBL.EQ L_tumor = L_tumor_sp * Mass_tumor GLOBL.EQ Q_tumor = .212 * Mass_tumor GLOBL.EQ Vi_tumor = Vi_tumor_sp * Mass_tumor GLOBL.EQ Vv_tumor = Vv_tumor_sp * Mass_tumor GLOBL.EQ B_max = B_max_sp * Mass_tumor PARAM B_max_sp VALUE 5.83000000e-010 LOWLIM 2.50000000e-011 HILIM 2.50000000e-005 ADJUST 0 PARAM FcRn_free VALUE 8.31000000e-009 LOWLIM 1.00000000e-011 HILIM 1.00000000e-005 ADJUST 0 PARAM J_iso_bone_sp VALUE 7.97965420e-005 LOWLIM 7.76003960e-006 HILIM 7.76000000e-004 ADJUST 0 PARAM J_iso_kidney_sp VALUE 5.21370000e-004 LOWLIM 5.08990000e-005 HILIM 5.08990000e-003 ADJUST 0 PARAM J_iso_liver_sp VALUE 2.82360000e-004 LOWLIM 1.31980000e-005 HILIM 1.31980000e-003 ADJUST 0 PARAM J_iso_lung_sp VALUE 1.19332000e-003 LOWLIM 1.17510000e-004 HILIM 1.17507000e-002 ADJUST 0 PARAM J_iso_muscle_sp VALUE 5.00000000e-006 LOWLIM 5.00000000e-007 HILIM 5.00000000e-005 ADJUST 0 PARAM J_iso_skin_sp VALUE 3.00000000e-005 LOWLIM 3.00000000e-006 HILIM 3.00000000e-004 ADJUST 0 PARAM J_iso_spleen_sp VALUE 1.85690000e-004 LOWLIM 1.79630000e-005 HILIM 1.79630000e-003 ADJUST 0 PARAM J_iso_tumor_sp VALUE 1.20263000e-003 LOWLIM 1.80330000e-004 HILIM 1.80325000e-002 ADJUST 0 PARAM L_bone VALUE 2.88850000e-004 LOWLIM 2.80360000e-005 HILIM 2.80360000e-003 ADJUST 0 PARAM L_gi VALUE 7.00000000e-004 LOWLIM 7.00000000e-005 HILIM 7.00000000e-003 ADJUST 0 PARAM L_heart VALUE 1.00000000e-005 LOWLIM 1.00000000e-006 HILIM 1.00000000e-004 ADJUST 0 PARAM L_kidney VALUE 3.12860000e-004 LOWLIM 3.05170000e-005 HILIM 3.05170000e-003 ADJUST 0 PARAM L_liver VALUE 3.27860000e-004 LOWLIM 1.58570000e-005 HILIM 1.58570000e-003 ADJUST 0 PARAM L_lung VALUE 1.46550000e-004 LOWLIM 1.43980000e-005 HILIM 1.43980000e-003 ADJUST 0 PARAM L_muscle VALUE 6.00000000e-004 LOWLIM 6.00000000e-005 HILIM 6.00000000e-003 ADJUST 0 PARAM L_skin VALUE 1.00000000e-005 LOWLIM 1.00000000e-006 HILIM 1.00000000e-004 ADJUST 0 PARAM L_spleen VALUE 4.21702230e-005 LOWLIM 4.00739280e-006 HILIM 4.00740000e-004 ADJUST 0 PARAM L_tumor_sp VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 7.50000000e-002 ADJUST 0 PARAM Q_bone VALUE 1.70000000e-001 LOWLIM 1.70000000e-002 HILIM 1.70000000e+000 ADJUST 0 PARAM Q_gi VALUE 9.00000000e-001 LOWLIM 9.00000000e-002 HILIM 9.00000000e+000 ADJUST 0 PARAM Q_heart VALUE 2.80000000e-001 LOWLIM 2.80000000e-002 HILIM 2.80000000e+000 ADJUST 0 PARAM Q_kidney VALUE 8.00000000e-001 LOWLIM 8.00000000e-002 HILIM 8.00000000e+000 ADJUST 0 PARAM Q_liver VALUE 1.10000000e+000 LOWLIM 1.10000000e-001 HILIM 1.10000000e+001 ADJUST 0 PARAM Q_muscle VALUE 8.00000000e-001 LOWLIM 8.00000000e-002 HILIM 8.00000000e+000 ADJUST 0 PARAM Q_skin VALUE 1.21000000e+000 LOWLIM 1.21000000e-001 HILIM 1.21000000e+001 ADJUST 0 PARAM Q_spleen VALUE 5.00000000e-002 LOWLIM 5.00000000e-003 HILIM 5.00000000e-001 ADJUST 0 PARAM R_bone VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_gi VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_heart VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_kidney VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_liver VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_lung VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_muscle VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_skin VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_spleen VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM R_tumor VALUE 1.00000000e+000 LOWLIM 1.00000000e-001 HILIM 1.00000000e+001 ADJUST 0 PARAM U VALUE 5.50000000e-005 LOWLIM 2.50000000e-011 HILIM 2.60000000e-003 ADJUST 0 PARAM V_plasma VALUE 7.74000000e-001 LOWLIM 7.74000000e-002 HILIM 7.74000000e+000 ADJUST 0 PARAM Vi_bone VALUE 2.80000000e-001 LOWLIM 2.80000000e-002 HILIM 2.80000000e+000 ADJUST 0 PARAM Vi_gi VALUE 6.00000000e-001 LOWLIM 6.00000000e-002 HILIM 6.00000000e+000 ADJUST 0 PARAM Vi_heart VALUE 1.90000000e-002 LOWLIM 1.90000000e-003 HILIM 1.90000000e-001 ADJUST 0 PARAM Vi_kidney VALUE 1.01000000e-001 LOWLIM 1.01000000e-002 HILIM 1.01000000e+000 ADJUST 0 PARAM Vi_liver VALUE 1.90000000e-001 LOWLIM 1.90000000e-002 HILIM 1.90000000e+000 ADJUST 0 PARAM Vi_lung VALUE 5.70000000e-002 LOWLIM 5.70000000e-003 HILIM 5.70000000e-001 ADJUST 0 PARAM Vi_muscle VALUE 1.03200000e+000 LOWLIM 1.03200000e-001 HILIM 1.03200000e+001 ADJUST 0 PARAM Vi_skin VALUE 9.99000000e-001 LOWLIM 9.99000000e-002 HILIM 9.99000000e+000 ADJUST 0 PARAM Vi_spleen VALUE 2.00000000e-002 LOWLIM 2.00000000e-003 HILIM 2.00000000e-001 ADJUST 0 PARAM Vi_tumor_sp VALUE 5.50000000e-001 LOWLIM 5.50000000e-002 HILIM 5.50000000e+000 ADJUST 0 PARAM Vv_bone VALUE 8.00000000e-002 LOWLIM 2.80000000e-002 HILIM 2.80000000e+000 ADJUST 0 PARAM Vv_gi VALUE 1.00000000e-001 LOWLIM 1.00000000e-002 HILIM 1.00000000e+000 ADJUST 0 PARAM Vv_heart VALUE 7.00000000e-003 LOWLIM 7.00000000e-004 HILIM 7.00000000e-002 ADJUST 0 PARAM Vv_kidney VALUE 3.00000000e-002 LOWLIM 3.00000000e-003 HILIM 3.00000000e-001 ADJUST 0 PARAM Vv_liver VALUE 9.50000000e-002 LOWLIM 9.50000000e-003 HILIM 9.50000000e-001 ADJUST 0 PARAM Vv_lung VALUE 1.90000000e-002 LOWLIM 1.90000000e-003 HILIM 1.90000000e-001 ADJUST 0 PARAM Vv_muscle VALUE 1.50000000e-001 LOWLIM 1.50000000e-002 HILIM 1.50000000e+000 ADJUST 0 PARAM Vv_skin VALUE 2.00000000e-001 LOWLIM 2.00000000e-002 HILIM 2.00000000e+000 ADJUST 0 PARAM Vv_spleen VALUE 1.00000000e-002 LOWLIM 1.00000000e-003 HILIM 1.00000000e-001 ADJUST 0 PARAM Vv_tumor_sp VALUE 7.00000000e-002 LOWLIM 7.00000000e-003 HILIM 7.00000000e-001 ADJUST 0 PARAM alpha_L VALUE 1.70000000e-002 LOWLIM -1.00000000e-001 HILIM 9.00000000e+000 ADJUST 0 PARAM alpha_S VALUE 9.84000000e-001 LOWLIM -1.00000000e-001 HILIM 9.80000000e+000 ADJUST 0 PARAM k(2,22) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(3,23) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(4,24) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(5,25) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(8,28) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(9,29) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(10,30) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(21,51) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(22,2) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(23,3) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(24,4) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(25,5) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(28,8) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(29,9) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(30,10) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(31,33) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(33,31) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k(51,21) VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k_af VALUE 9.84000000e-002 LOWLIM 8.00000000e-002 HILIM 8.00000000e+000 ADJUST 0 PARAM k_af_bone VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.50000000e-002 ADJUST 0 PARAM k_af_gi VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.00000000e-001 ADJUST 0 PARAM k_af_heart VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-002 ADJUST 0 PARAM k_af_kidney VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.20000000e-001 ADJUST 0 PARAM k_af_liver VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.00000000e-002 ADJUST 0 PARAM k_af_lung VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 4.00000000e-002 ADJUST 0 PARAM k_af_muscle VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.50000000e-002 ADJUST 0 PARAM k_af_skin VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.50000000e-002 ADJUST 0 PARAM k_af_spleen VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 3.00000000e-003 ADJUST 0 PARAM k_af_tumor VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k_ar VALUE 8.46000000e-004 LOWLIM 8.46000000e-005 HILIM 8.50000000e-002 ADJUST 0 PARAM k_ar_bone VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 8.50000000e-002 ADJUST 0 PARAM k_ar_gi VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 4.00000000e-002 ADJUST 0 PARAM k_ar_heart VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 5.00000000e-003 ADJUST 0 PARAM k_ar_kidney VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-002 ADJUST 0 PARAM k_ar_liver VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 7.00000000e-003 ADJUST 0 PARAM k_ar_lung VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 2.00000000e-002 ADJUST 0 PARAM k_ar_muscle VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 5.00000000e-003 ADJUST 0 PARAM k_ar_skin VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 5.00000000e-003 ADJUST 0 PARAM k_ar_spleen VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 5.00000000e-004 ADJUST 0 PARAM k_ar_tumor VALUE 0.00000000e+000 LOWLIM -1.00000000e-001 HILIM 1.00000000e-001 ADJUST 0 PARAM k_deg_IgG VALUE 1.14345730e-001 LOWLIM 7.44185000e-003 HILIM 7.44184800e-001 ADJUST 0 PARAM k_int_IgG VALUE 1.38367900e-002 LOWLIM 1.34400000e-003 HILIM 1.34400000e-001 ADJUST 0 PARAM k_off_IgG VALUE 1.14000000e-001 LOWLIM -1.00000000e-001 HILIM 1.14000000e+000 ADJUST 0 PARAM k_on_IgG VALUE 5.18000000e+009 LOWLIM -1.00000000e-001 HILIM 5.18000000e+010 ADJUST 0 PARAM k_rec_IgG VALUE 2.13675000e-003 LOWLIM 2.27210000e-004 HILIM 2.27209000e-002 ADJUST 0 PARAM sigma_a_L VALUE 2.60000000e-001 LOWLIM 2.60000000e-002 HILIM 2.60000000e+000 ADJUST 0 PARAM sigma_a_S VALUE 9.80000000e-001 LOWLIM 9.80000000e-002 HILIM 9.80000000e+000 ADJUST 0 NOTES UNITS Volume = ml Mass = g Flow rate = ml/min Concentration = mol/ml kf_non-specific = min^-1 kf_specific = ml/(min*pmol) kr_specific = min^-1 ~ END STARTDATA DATA t Tumor Blood Liver Spleen Kidney Lung Bone 0 0.90 (0.11) 38.32 (0.426) 7.90 (1.04) 3.48 (0.51) 6.38 (0.88) 15.24 (1.38) 1.85 (0.22) 360 17.34 (2.70) 26.35 (0.066) 5.89 (0.26) 4.13 (0.10) 5.83 (0.32) 10.44 (0.62) 2.18 (0.30) 780 31.81 (7.82) 21.46 (0.214) 4.03 (0.50) 3.66 (0.50) 5.23 (0.19) 9.31 (1.31) 1.88 (0.25) 1440 41.33 (2.35) 17.43 (0.153) 4.08 (0.18) 3.01 (0.15) 4.04 (0.19) 8.52 (0.47) 1.56 (0.21) 2880 42.62 (9.10) 13.23 (0.204) 2.69 (0.21) 1.92 (0.19) 2.55 (0.41) 5.67 (1.34) 1.28 (0.08) 4320 47.45 (9.87) 11.74 (0.198) 3.28 (0.63) 2.20 (0.51) 2.67 (0.46) 6.34 (1.45) 1.17 (0.18) 5760 33.46 (7.40) 10.68 (0.238) 2.28 (0.35) 1.78 (0.34) 2.23 (0.62) 4.57 (0.89) 0.94 (0.26) 7200 35.78 (9.00) 5.50 (0.205) 1.77 (0.42) 0.95 (0.24) 1.16 (0.37) 2.37 (0.76) 0.53 (0.26) 10080 15.20 (3.43) 2.29 (0.106) 1.07 (0.34) 0.48 (0.20) 0.64 (0.29) 1.10 (0.51) 0.31 (0.11) END ENDDATA