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RECENT
PUBLICATIONS
Fox, J., Brown, N. "Sensitivity and Consistency of Affymetrix GeneChip Normalization Methods." Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, Massachusetts, USA; 14–17 October 2007: p 1081-1086. 2007.
Fox, J., Brown, N. "Automatically Extracting Acronyms from Biomedical Text." Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering. Boston, Massachusetts, USA; 14–17 October 2007: p 1245-1248. 2007.
Fox, J., Brown, N. "Data Dependencies in the Quantitation of Affymetrix Gene Expression Data." Proceedings of the WCECS International Conference on Computational Biology. San Francisco, California, USA; 24-26 October, 2007: p 29-33. 2007.
M Eisenberg, M Samuels and JJ DiStefano III, L-T4 "Bioequivalence and Hormone Replacement Studies via Feedback Control Simulations". Thyroid, 16(12): 1-14, Dec 2006
http://www.liebertonline.com/toc/thy/16/12
GZ Ferl, V Kenanova, AM Wu and JJ DiStefano III. "A two-tiered physiologically-based model for dually labeled single chain Fv- Fc antibody fragments. Molecular Cancer Therapeutics. 5(6):1550-1558, 2006.
http://mct.aacrjournals.org/cgi/content/full/5/6/1550
S Hori, I Kurland and JJ DiStefano III. "Role of Endosomal Trafficking Dynamics on the Regulation of Hepatic Insulin Receptor Activity: Models for Fao Cells. Annals of Biomedical Engineering. 34(5):879-92, 2006.
http://www.springerlink.com/content/u6234212174jr515/
S Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine. 83(1): 34-42, 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007
Javier RM and JJ DiStefano III. Modeling the Dynamics of Biocontrol Systems Mechanistically. Proceedings of the 5th IFAC MATHMOD Conference, Vienna, Feb 2006.
S. Russell and JJ DiStefano III. W3MAMCAT: A Worldwide Web Based Expert System For Mammillary & Catenary Compartmental Modeling & Distinguishability. Computer Methods and Programs in Biomedicine, 83:34-42, July 2006. http://dx.doi.org/10.1016/j.cmpb.2006.03.007
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Lab PhD student Marisa Eisenberg is an NIH Fellow for 2007-2008.
Lab senior and Cybernetics major, Robyn Javier, received
the prestigious 2004 UCLA LEADS Award. On November 13, 2004,
Robyn received the Oral Presentation Award
in Quantitative Sciences at the 2004 Annual Biomedical Research Conference
for Minority Students, Dallas, TX. She has also received the
Charles E. and Sue K. Young Undergraduate Student Award for 2004-2005, for "exemplary
academic achievement, university citizenship and community involvement."
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Dynamic Systems Biology Modeling Seminar
4:15 pm Fridays, Boelter Hall 4760
(4th Floor Conference Room)
KINETICS AND TIMING OF VIRAL INFECTIONS
Tom Chou
Associate Professor,
Depts. of Biomathematics and Mathematics
Friday May 16 2008 4 PM
Boelter 4764
Abstract
The infection of eukaryotic cells by enveloped viruses is a complex process that involves entry through both plasma and nuclear membranes. I will discuss a stochastic model of entry through the plasma membrane that incoroprates both fusion and endocytotic mechanisms. Parameters at which each entry pathway is more probable are mapped out. Some discussion on cytoplasmic transport and entry into the nucleus will also be presented.
POSITRON EMISSION TOMOGRAPHY (PET) & TRACER KINETIC MODELING APPLIED TO MOUSE MODELS OF CANCER
Presented by Dr. Greg Ferl, SOMI Fellow, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology, UCLA
April 18th, 2008 4:15 PM
Positron emission tomography (PET), typically used to visualize human tumors in a clinical setting, is also capable of visualizing molecular processes in rats and mice. PET can track tracer kinetics within a single animal over time, permitting quantification of tracer dynamics within various tissues. In this talk, we present a novel method for estimating blood concentration over time of 18F-FDG, a glucose analog and common PET tracer, in a single anesthetized mouse during a dynamic PET scan using a Bayesian/population kinetics compartmental modeling approach. This is a challenging problem in 18F-FDG PET studies due to very small murine blood volume. We also present a quantitative kinetic analysis of a novel small molecule RGD peptide PET tracer, to validate the putative physiological significance of particular model compartments. This novel molecule targets a specific tumor integrin.
For workshop information, please contact Sharon Hori at seiko24[AT]ucla.edu.